| 皮肤光老化组织学改变研究进展 |
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| 引用本文： | 姚露,何黎.皮肤光老化组织学改变研究进展[J].国际皮肤性病学杂志,2010,36(2). |
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| 作者姓名： | 姚露 何黎 |
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| 作者单位： | 昆明医学院第一附属医院皮肤科,650000 |
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| 摘 要： | 皮肤光老化是不断累积的日光照射所致的一个连续性过程,是指长期的日光照射(主要是紫外线)导致皮肤衰老.在组织学方面,表皮变化主要是角质形成细胞、黑素细胞、朗格汉斯细胞,真皮变化主要是弹力纤维变性和胶原减少.其机制主要涉及免疫系统、细胞因子改变、基质金属蛋白酶生成增加、活性氧簇增加及DNA损伤等.概述并探讨皮肤光老化组织学变化及其相应的发生机制.
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| 关 键 词： | 光 细胞衰老 组织学 |
Histological changes of photoaged skin |
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| Abstract: | Photoaging of human skin is a continuous process induced by chronic exposure to sun light, especially ultraviolet rays. Histologically, photoaged skin is characterized by elastosis, collagen decrease and alterations in epidermal keratinocytes, melanocytes and Langerhans cells. The mechanism of skin photoaging is mainly related to immune system, cytokine change, increase in the production of matrix metalloproteinase and active oxygen, DNA damage, etc. This review presents histological changes of photoaged skin and their mechanism. |
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| Keywords: | Light Cell aging Histology |
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