褶合光谱法考察诺氟沙星与常用注射液的配伍稳定性

目的:考察室温下8h内诺氟沙星与7种常用注射液(5%葡萄糖注射液,10%葡萄糖注射液,5%葡萄糖氯化钠注射液,10%葡萄糖氯化钠注射液,复方氯化钠注射液,0.9%氯化钠注射液,乳酸钠注射液)的配伍稳定性。方法:采用褶合光谱法,并结合外观和pH值检查法,以差谱值予以定量表达。结果:诺氟沙星与上述常用注射液配伍后在8h内,外观均无变化,pH值变化不显著,除诺氟沙星与乳酸钠注射液配伍在4、6、8h的褶合光谱的差谱值分别为11.51%,19.73%,24.81%外,其余各差谱值均小于10%。结论:室温下8h 内,除诺氟沙星与乳酸钠注射液不能配伍外,与其余6种常用输液均能配伍使用,褶合光谱法为药物稳定性研究提供了一个新的手段。

Observation on the stability on infusions mixed with norfloxacin by convolution spectrometry

Objective: To observe the chemical stabihty of seven common injections (5% glucose injection, 10% glucose injection, 5% glucose and sodium chloride injection, 10% glucose and sodium chloride injection, compound sodium chloride injection, 0. 9% sodium chloride injection, sodium lactate injection) mixed with norfloxacin at room temperature for 8 hours. Methods: A convolution spectrometry was used, the appearance was observed and pH value was tested. The results were described quantitatively by subtract spectrometry value. Results: There were no obvious changes in the appearances and pH in 8 hours. Except that the subtract spectrometry values of norfloxacin with sodium lactate injection in 4, 6, 8h were 11.51% ,19.73% ,24.81% , the others were less than 10%. Conclusion:Norfloxacin can be mixed with other common injections except sodium lactate injection at room temperature for 8 hours. The convolution spectrometry provides a new method for the research of the stability of drugs.