高压氧治疗新生儿缺氧缺血性脑病疗效分析

目的：探讨高压氧对于新生儿缺氧缺血性脑病（HIE）的治疗作用。方法：2001年5月-2004年6月的新生儿缺氧缺血性脑病患儿49例，高压氧治疗组24例给予高压氧结合常规治疗；对照组25例仅给予常规治疗。观察两组血清肌酸激酶（CK），生后7、14、28d的新生儿20项行为神经测定（NBNA）以及生后3、6、12、18和24个月的CDCC智能发育评估。结果：高压氧组的CK明显低于对照组，而NBNA、CDCC明显优于对照组。结论：高压氧治疗对新生儿缺氧缺血性脑病有明显的近期和远期神经保护作用。

A study of protective effect of hyperbaric oxygenation treatment on neonatal hypoxia-ischenlia encephaloathy

Objective： To investigate the short and long term neuroprotective effects of hyperbaric oxygenation treatment on neonatal HIE. Methods： Fourty-nine asphyxiated newborn infants in our hospital were randomly divided into either hyperbaric oxygenation treatment group（HBOG）（n=24） or normorhermia group（NG）（n=25）.The infants in HBOG got hyperbaric oxygenation treatment for 1 hour every day. The other supportive treatments were the same in both groups. Serum CK tevel, neonatal behavioral neurological assessment（NBNA） and intellectual development table made by Children＇s development center of China （CDCC） were proceeded to evaluate the protective effects of hyperbaric oxygenation treatment on neonatal HIE. Results：①Serum CK level, Serum CK level lowered significantly after treatment in HBOG than that of NG.②NBNA, the score of NBNA was much higher at 7,14 and 28 d in HBOG than that of NG.③CDCC assessment, significant higher score of MDI and PDI was found at 3、6、12 and 18 month age in HBOG than that of NG. Conclusion： There are short and long term neuroproteetive effects of hyperbaric oxygenation treatment on neonatal HIE.