1685株鲍曼不动杆菌的临床分布及耐药性研究

目的探讨川北医学院附属医院鲍曼不动杆菌感染的临床分布和耐药特点,为该菌的感染治疗与预防提供依据。方法该院2011~2014年住院患者送检标本中分离的1 685株鲍曼不动杆菌的分布及耐药性检测。结果鲍曼不动杆菌主要分离自痰液标本,占73.1%;以重症监护病房和神经外科病房检出率最高;该菌仅对头孢哌酮/舒巴坦和米诺环素耐药率低,分别为27.9%和26.9%;对亚胺培南、美罗培南的耐药率分别为77.4%、73.9%;对其余多种抗菌药物耐药率在62.0%以上。结论鲍曼不动杆菌的耐药率较高并具有多重耐药性,临床治疗应及时进行细菌耐药性监测并根据药敏试验结果选择合适的抗菌药物。

Clinical distribution and antibiotics resistance of 1 685 strains of Acinetobacter baumannii

Objective To investigate the clinical distribution and antibiotics resistance of Acinetobacter bau‐mannii in Affiliated Hospital of North Sichuan Medical College and in order to provide evidence for clinical treatment and prevention of Acinetobacter baumannii infection .Methods A retrospective statistical analysis was performed on the clinical distribution and antibiotics resistance results of 1 685 Acinetobacter baumannii isolates from inpatient be‐tween 2011 and 2014 .Results Most of the Acinetobacter baumannii isolates were isolated from sputum specimens (73 .1% ) .Patients who infected by Acinetobacter baumannii were found mainly from the intensive care unit ward and neurosurgery department .More than 62 .0% of Acinetobacter baumannii isolates were resistant to all the the antibac‐terial agents tested except cefoperazone‐sulbactam (the resistance rate was 27 .9% ) and minocycline(the resistance rate was 26 .9% ) ,About 74 .0% and 73 .1% of these strains were resistant to imipenem and meropenem ,respective‐ly .Conclusion The Acinetobacter baumanii strains had seriously resistant and multidrud‐resistant to many kinds of antibiotics except of cefoperazone‐shubatan and minocycline .Clinicians should monitor the antibiotics resistance of Acinetobacter baumanii timely and choose proper antibacterial agents according to the results of drug sensitively .