血流感染患者D-二聚体测定的临床意义

目的探讨急性血流感染(BSI)患者血浆D-二聚体的水平及临床意义。方法胶乳增强免疫比浊法检测111例BSI患者和38例非BSI患者的血浆D-二聚体水平,比较两组D-二聚体水平的差异。结果 BSI患者的D-二聚体水平[2.034(1.190~4.666)mg/L]明显高于非BSI者[0.966(0.157~2.056)mg/L],差异有统计学意义(P0.01);BSI患者革兰阳性球菌感染组的D-二聚体水平[2.054(1.097~4.768)mg/L]与革兰阴性杆菌感染组[1.824(1.291~4.814)mg/L]相比,差异无统计学意义(P0.05)。结论 BSI患者体内存在着凝血和纤溶活性的异常,D-二聚体可作为非特异性炎性指标,辅助血流感染患者病情及疗效的监测。

Clinical significance of plasm D-dimer detection in patients with bloodstream infection

Objective To investigate the level and clinical significances of plasma D‐dimer in the patients with the acute blood stream infection (BSI) .Methods The latex enhanced immune turbidimetric method was adopted to detect plasma D‐dimer level in 111 cases BSI and 38 cases of non‐BSI .The detection results were compared between BSI and non‐BSI .Results The D‐dimer level in the BSI patients was 2 .034(1 .190 - 4 .666)mg/L ,which was signifi‐cantly higher than 0 .966 (0 .157 - 2 .056)mg/L in the non‐BSI patients ,the difference was statistically significant (P< 0 .01) ;the D‐dimer level had no statistical difference between the Gram‐positive cocci infection and Gram‐nega‐tive bacilli infection[1 .824(1 .291 - 4 .814)mg/L vs .[2 .054(1 .097 - 4 .768) mg/L ,P> 0 .05] .Conclusion The ab‐normality of coagulation and fibrinolysis activity exists in the BSI patients .D‐dimer can be used as a nonspecific in‐flammation index for auxiliarily monitoring the disease condition and curative effect in the BSI patients .