| P—170在复发难治性白血病中的表达及临床意义 |
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| 引用本文： | 李晓明,吴谨绪.P—170在复发难治性白血病中的表达及临床意义[J].泸州医学院学报,1996,19(4):260-262. |
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| 作者姓名： | 李晓明 吴谨绪 |
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| 作者单位： | 泸州医学院附属医院血液科!646000(李晓明)，华西医科大学附一院血液科(吴谨绪)，兰州医学院附二院血液科(张连生) |
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| 摘 要： | 急性白血病的复发与难治和白血病发生多药耐药（multidrugresistance，MDR）有关，发生MDR现象的主要机制是多药耐药基因（mdr；基因）的过度表达，mdr；基因的表达产物为定位于细胞膜上．分子量为170KDa的糖蛋白（Glycoproteins，P-170），为探讨P－170在复发难治性白血病中的表达及临床意义，用免疫组织化学ABC法检测了48例复发难治性白血病的P－170表达，其，阳性表达率为77．1％．结果表明：P－170在复发难治性白血病中有高度表达，本方法检测白血病MDR及对逆转白血病的MDR有一定的临床意义及指导意义．
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| 关 键 词： | 白血病 多药耐药（MDR） 复发与难治 糖蛋白类（P－170） |
EXPRESSION OF P-170 IN RELAPSING AND REFRACTORY LEUKEMIA AND ITS CLINICAL SIGNIFICANCE |
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| Li Xiaoming,et al.EXPRESSION OF P-170 IN RELAPSING AND REFRACTORY LEUKEMIA AND ITS CLINICAL SIGNIFICANCE[J].Journal of Luzhou Medical College,1996,19(4):260-262. |
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| Authors: | Li Xiaoming |
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| Institution: | Department of Hematology |
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| Abstract: | The relapse and refractoriness of leukemia are associated with the occurrence of mul-tidrug resistance (MDR) whick is the result of mdrl gene expression and the excessive production ofP-170. The expression of P-170in 48 sases of relapsing and refractory leukemia was examined bymeans of immunocytoehemistry ABC method) and direct monoclonal antibodies JSB-1. The incidenceof P-1170 is up to 77. 1 %. The result showed that P-170 hase positive relation with relapsing and re-fractory leukemia and this mathod hase clinical significance in reversing the MDR of relapsing an-drefactory leukemia. |
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| Keywords: | Leukemia Relapse and refractory MDR P-1170 (Glycoprotein) |
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