血液透析患者肺功能与炎性标志物的关系

目的探讨血液透析患者的肺功能与血清超敏C-反应蛋白（hs-CRP）、白蛋白（Alb）及铁蛋白（Ferr）水平之间的相关性。方法选择安徽医科大学第一附属医院血液净化中心门诊和住院血液透析超过3个月的患者108例，根据患者的血清hs—CRP、白蛋白、铁蛋白水平将其分别为两组（hs—CRP≥10mg／L、hs-CRP〈10mg／L；Alb≥35g／L、Alb〈35g／L；Ferr≥150μg／L、Ferr〈150μg／L），测定并比较两组间患者肺功能差异。结果通过测量用力肺活量（FVC）、第1秒用力呼气容积（FEV1）、呼吸峰流量（PEF）来检测肺功能，数据以FVC％，FEV1％，和PEF％呈现，CRP≥10μg／ml的患者相比CRP正常患者年龄更大；FEV1％，FVC％和PEF％水平更低（P=0．005，P=0．001，P=0．015）。铁蛋白≥150仙g／L和铁蛋白正常患者相比，FEV1％（P=0．035）、FVC％（P=0．019）和PEF％（P=0．021）三项也均有显著差异，白蛋白和肺功能检测指标间无显著统计学意义差异。结论血液透析患者血清CRP、铁蛋白水平增高可能与肺功能障碍具有相关性。

Relation between Pulmonary Function and Inflammatory Biomarkers in Hemodialysis Patients

Objective To investigate the relationship between pulmonary function and serum levels of high-sensitivity C-reactlve protein （hs-CRP）, ferritin, and albumin, as inflammatory biomarkers, in hemodialysis patients. Methods one hundred and eight pa- tients, who were dialyzed at least for 3 months both in outpatient and in hospital of hemodialysis department, were included in this study. Patients＇ blood samples were collected ,which were divided into two groups respectively according to their levels（ hs-CRP≥10 mg/L,hs-CRP 〈 10 mg/L;Alb≥35 g/L,Alb 〈35 g/L;Ferr≥ 150μg/L,Ferr 〈150μg/L, respectively）,and pulmonary function tests,forced vital capacity （FVC） , forced expiratory volume in the first second （FEVl ） , and peak expiratory flow （PEF） were measured and expressed as the % predicted using appropriate normal values for the patients＇ sex, age, and height （FVC% , % FEV1% , and PEF% ）, at the same time. Result The patients with CRP≥10 μg/ml were significantly older and had lower values of, FEV1% ,FVC% and PEF% （P = 0.005, P = 0. 001, and P =0.015, respectively） ; also FEV1% （ P = 0. 035 ）, FVC% （ P = 0. 019） and PEF% （ P =0.021 ） had significant differences between the patients with ferritin ≥150 μg/L and other patients. However, no other significant differences were found between inflammatory biomarkers and the pulmonary function tests. Conclusion Inflammation has a close relation with pulmonary dysfunction in hemodialysis patients.