| 关注某些医用产品中丙烯酰胺的潜在风险 |
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| 引用本文： | 程鲁榕.关注某些医用产品中丙烯酰胺的潜在风险[J].中国药物警戒,2006,3(2):89-92. |
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| 作者姓名： | 程鲁榕 |
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| 作者单位： | 国家食品药品监督管理局药品审评中心,北京,100038 |
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| 摘 要： | 根据世界卫生组织发布的有关文件。简要概述了丙烯酰胺以及代谢产物在动物方面的研究和有限的人体研究情况．主要涉及神经毒性、生育毒性、致癌性和遗传毒性及其可能发生的机制等。结果表明：丙烯酰胺引起的神经毒性可能与丙烯酰胺有关；导致动物多器官肿瘤的发生与丙烯酰胺的代谢产物环氧丙酰胺有关。
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| 关 键 词： | 丙烯酰胺 环氧丙酰胺 毒性 世界卫生组织 |
| 文章编号： | 1672-8629（2006）02-0089-04 |
| 收稿时间： | 2005-11-29 |
| 修稿时间： | 2005年11月29 |
Pay attention to the latent risk of Acrylamide effects in some medicine products |
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| CHENG Lu-rong.Pay attention to the latent risk of Acrylamide effects in some medicine products[J].Chinese JOurnal of Pharmacovigilance,2006,3(2):89-92. |
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| Authors: | CHENG Lu-rong |
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| Institution: | Center For Drug Evaluation, SFDA (Beijing 100038,China |
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| Abstract: | This paper summarized that the animal studies of acrylamide and its major metabolite,glycidamide, also including the limited study on human according to the relevant document that WHO release.The studies mainly were involved in the neurotoxicity, fertility,genotoxicity,carcinogenicity and its mechanism,separately.The results enunciation:The neurotoxicity probably relates with acrylamide and the animal tumor outcome occurring in some organs probably relates with glycidamide . |
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| Keywords: | acrylamide glycidamide toxicity WHO |
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