0级糖尿病足中医证型与凝血和免疫因子的相关性研究

目的:总结0级糖尿病足(Dinbetic Foot,DF)中医证型分布规律并探讨0级DF不同中医证型与凝血、免疫相关指标的关系。方法:将60例0级DF患者按照辨证分型标准进行中医证型分类,并记录和比较各型0级DF患者、30例单纯糖尿病患者及30例健康人的凝血、免疫指标等。结果:1)凝血方面:0级DF组的PT高于单纯糖尿病组、健康人组的PT,且差异有统计学意义(P0.05);0级DF组的ACT和TT均低于单纯糖尿病组和健康人组,且差异有统计学意义(P0.05)。2)免疫方面:0级DF组与单纯糖尿病组、健康人组比较,0级DF组IgM、IgG、C3、C4均较单纯糖尿病组、健康人组高,差异均有统计学意义(P0.05)。3)0级DF中医证型与凝血和免疫指标关系:肝肾亏虚型的PT较高,气虚血瘀型的ACT、TT高于阴虚血瘀、痰瘀阻络型;IgG、IgA、C3均以阴虚血瘀型升高明显,且以上差异均有统计学意义(P0.05)。结论:0级DF存在着凝血和免疫机制的问题,凝血中的PT、ACT与TT,免疫中的IgG、IgA与C3均与0级DF中医证型间存在着一定的相关性。

Study on the Relations between TCM Syndromes and Coagulation and Immune Factors of Zero Degree of Diabetic Foot

Objective：To summarize the distribution pattern of TCM syndromes of 0 degree Diabetic Foot （DF）and to analyze the rela-tions between TCM syndromes and coagulation and immune factors.Methods：Sixty patients with 0 degree DF were classified in accord-ance with their TCM syndromes,and coagulation index and immune factors of the 60 patients with 0 degree DF,30 patients with simple diabetes and 30 healthy people were recorded.Results：1 ）As for coagulation,PT level of the 0 degree DF group was higher than that of the diabetic group and healthy people group,and the difference was statistically significant （P〈0.05）;the levels of ACT and TT in 0 degree DF group were lower than those of the diabetic group and the healthy control group,and the differences were statistically signifi-cant.2）As for immune factors,the levels of IgM,IgG,C3,C4 of the 0 degree DF group were higher than those of the diabetes group and the healthy control group,and there were significant differences.3）The relationship between 0 DF TCMsyndromes and coagulation, immune factors：PT level in the liver and kidney deficiency type was higher than that of the other types.The levels of ACT and TT in qi deficiency and blood stasis type were higher than those of the Yin deficiency and blood stasis type and blood stasis and phlegm type.The levels of IgG,IgA and C3 were significantly elevated in Yin deficiency and blood stasis type.Those differences have statistical signifi-cance.Conclusion：There are problems of coagulation and immune mechanism existed in the 0 degree DF.The levels of ACT,TT of coagulation,as well as immune factors of IgG,IgA,C3 are relevant to TCM syndromes of 0 degree DF.