前列地尔联合百令胶囊治疗急性肾损伤435例临床研究

目的:观察前列地尔注射液联合百令胶囊对急性肾损伤的疗效并探讨其作用机制。方法:将436例急性肾损伤患者随机分为前列地尔组、百令胶囊组、联合治疗组,在给予一般治疗的基础上分别给予前列地尔注射液、百令胶囊及联合治疗,疗程4周,于治疗前后测尿微量白蛋白排泄率、血清肌酐、尿素、胱抑素C等。结果:与单用前列地尔注射液或百令胶囊比较,联合治疗使尿微量白蛋白排泄率、肌酐、尿素、胱抑素C进一步下降(P0.05)。结论:前列地尔注射液联合百令胶囊对急性肾损伤的疗效可靠,且较单用其中一种药物具有更强的肾脏保护作用。

Clinical Research on Alprostadil Combined with Bailing Capsule in Treating 435 Cases of Acute Kidney Injury

Objective：To observe the therapeutic effect of Alprostadil injection combined with Bailing capsule on patients with acute kidney injury and explore its mechanism of action.Methods：Four hundred and thirty six cases of acute kidney injury were randomly di-vided into alprostadil group,bailing capsule group,combined treatment group.Except from the routine treatment,patients in the three groups were respectively given Alprostadil Injection,bailing capsule and the combined treatment for 4 weeks.The levels of urinary albu-min excretion rate,serum creatinine,urea,cystatin C before and after treatment were measured.Results：Compared with the only appli-cation of Alprostadil injection or corbrin capsule,the combination therapy further decreased the levels of the urinary albumin excretion rate,creatinine,urea,Cystatin C （P〈0.05）.Conclusion：Alprostadil injection combined with Bailing capsule is effective for acute kid-ney injury is reliable,and has stronger renal protective effect than the single use of one drug.