宫连消颗粒质量标准研究

目的:研究并制定宫连消颗粒的质量标准。方法:对江苏江阴天江药业有限公司生产的宫连消颗粒剂中主要影响质量的赤芍、白芍、盐续断以及酒山茱萸进行薄层色谱鉴别,采用高效液相色谱法法检测方中君药赤芍、白芍含量,并完成中国药典颗粒剂下要求项目的检查,在此基础上建立质量标准。结果:色谱图上相应位置出现相同斑点,实验中三批宫连消颗粒中芍药苷的含量在5.12~6.06 mg/g之间。结论:宫连消颗粒中必须含有主要影响质量的赤、白芍、盐续断以及酒山茱萸,含赤芍、白芍以芍药苷计,含量暂定不得少于3.50 mg/g。

Study on Quality Standards of Gonglianxiao Granules

To build up quality standards of Gonglianxiao granules.Methods：The main influential medicinal herbs of Radix Paeoniae Rubra,Radix Paeoniae Alba,Radix Dipsaci and Fructus Corni from Tianjiang Pharmaceutical Ltd.in Jiangyin,Jiangsu Prov-ince were determined and submitted to TLC identification and HPLC identification.On the basis of the examinations,the quality stand-ard of Gonglianxiao Keli was built up.Results：We could get the corresponding spot of the testing and positive control samples at the corresponding place in the thin layer plate.The average content of paeoniflorin was between 5.1 2 mg/g and 6.06 mg/g.Conclusion：It is suggested by the present study that the quality standards of Gonglianxiao granules should be arranged as follows：Radix Paeoniae Rubra,Radix Paeoniae Alba,Radix Dipsaci and Fructus Corni must be included,and the average content of paeoniflorin shall not be lower than 3.50 mg/g.