中医药对肿瘤免疫抑制微环境的调控作用及分子机制研究

中医药是我国肿瘤治疗的重要手段之一,其治疗肿瘤的主要优势在于改善机体的内环境,重塑肿瘤相关微环境。该作用特点与近年来现代医学对肿瘤的治疗研究以肿瘤微环境为治疗新靶标的研究策略不谋而合。本文介绍了肿瘤免疫抑制微环境的形成和作用,并从重塑肿瘤微环境免疫抑制细胞和增强肿瘤免疫应答两方面介绍了中医药对肿瘤免疫微环境的调控作用及其分子机制,揭示了中医药调节肿瘤免疫微环境的双向性和多靶点机制,为中医药抗肿瘤和临床实践提供新的理论依据。

Regulating Effects and Molecular Mechanisms of Traditional Chinese Medicine in the Tumor Immune Suppressive Environment

TraditionalChinesemedicine（TCM）isanimportantapproachfortreatingcancerinChina.Itsmechanismsrelatetoregulate the bodys internal environment and remodel the tumor microenvironment （TME）,which coincided with modern cancer treatment views targeting on the TME.Here we introduce how TME reforming and its functions in tumorigenesis,and furthermore illustrate the effects and mechanisms of TCM regulating TME via reshaping immunosuppressive cells and enhancing anti-tumor immune responses.We also reveal the TCMs bidirectional and multi-targeting functions on regulating TME.Hopefully,it provides new theoretical basis for TCM clinical practice in the cancer treatment and prevention.