超敏C反应蛋白变化与缺血性脑卒中的研究

目的探讨超敏C反应蛋白（hs—CRP）在缺血性脑卒中发病过程中的变化及其与预后的关系。方法采用免疫比浊法动态检测82例缺血性脑卒中患者及20名正常对照者的hs—CRP变化，分析hs—CRP与梗死面积大小，病情和预后的相关性。结果缺血性脑卒中患者hs-CRP水平与病情及预后关系密切，其中大面积梗死组hs-CRP升高，持续时间长，神经功能缺损程度越重，预后越差；与中、小面积梗死组比较，差异有非常显著统计学意义（P〈0．01）。结论缺血性卒中患者hs-CRP水平可作为判断病情及预后的客观指标，hs—CRP越高，持续时间越长，预后越差。

Research of relationship between the kinetic changes of high-sensitive C-reactive protein level and in patients with Ischemic Stroke

Objective To investigate the association between the kinetic changes of high-sensitive C-reactive protein level and prognosis during the progression of Isehemic Stroke. Methods High-sensitive C-reactive protein levels of 82 patients with Ischemic Stroke and 20 healthy volunteers served as a control group were tested with immtmoturbidimctric assay and were analyzed whether to correlate with severity and outcome after Isehemie Stroke. Results There was the significant correlation between high-sensitive C-reactive protein levels and severity, prognosis in patients with Isehemic Stroke. High-sensitive C-reactive protein levels in larger Infarction group was higher and lasted longer than that in middle and smaller infarction groups, the difference was Statistically significant obviously （P 〈 0.01）. High levels of high-sensitive C-reactive protein inlarger infarction group indicated more severe neurologic functional impairment and worse prognosis. Conclusion High-sensitive C-reactive protein is as ignificant risk factor for severity and prognos is in patients with Ischemie Stroke. If high-sensitive C-reactive protein levels are high and last long, the patients with Isehemic Stroke have unfavourable prognosis.