| 阿霉素微球的制备工艺的优选 |
| |
| 引用本文： | 靳浩,梅兴国. 阿霉素微球的制备工艺的优选[J]. 中国医院药学杂志, 2006, 26(5): 585-588 |
| |
| 作者姓名： | 靳浩 梅兴国 |
| |
| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850 |
| |
| 摘 要： | 目的:研究阿霉素PLGA(乳酸-羟基醋酸共聚物)微球制备的最佳工艺。方法:采用“复乳-液中干燥”法制备阿霉素PLGA微球。通过正交试验结合多指标综合评价法优选最佳制备工艺。结果:通过对正交实验Z值结果进行分析,最佳制备工艺为:A3B1C1。结论:正交试验结合多指标综合评价法用于载药微球的制备工艺优化实用有效。
|
| 关 键 词： | 阿霉素 微球 乳酸-羟基乙酸共聚物 正交设计 |
| 文章编号： | 1001-5213(2006)05-0585-04 |
| 收稿时间： | 2005-09-08 |
| 修稿时间： | 2005-09-08 |
Preparation of adriamycin PLGA microspheres by orthogonal design |
| |
| JIN Hao,MEI Xing-guo. Preparation of adriamycin PLGA microspheres by orthogonal design[J]. Chinese Journal of Hospital Pharmacy, 2006, 26(5): 585-588 |
| |
| Authors: | JIN Hao MEI Xing-guo |
| |
| Affiliation: | Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China |
| |
| Abstract: | OBJECTIVE To study the optimum preparation conditions of adriamycin PLGA microspheres.METHODS Adriamycin PLGA microspheres were prepared by double emulsion method.The optimum preparation conditions were selected with orthogonal design combined with multi-index test. RESULTS According to Z-score results,the optimum preparation conditions of adriamycin PLGA microspheres was: A_(3)B_(1)C_(1).CONCLUSION Orthogonal design combined with multi-index test can be used to represent the most desirable variables in preparating drug-loaded microspheres. |
| |
| Keywords: | adriamycin microspheres PLGA orthogonal design |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
