白茅根煎剂联合干扰素和利巴韦林治疗慢性丙型肝炎的临床研究

目的:观察白茅根煎剂联合聚乙二醇干扰素α-2a(PEG-IFNα-2α,派罗欣)和利巴韦林治疗慢性丙型肝炎的抗病毒疗效并探讨其机理,同时观察白茅根煎剂对抗病毒治疗不良反应的影响。方法:将100例基因1b型慢性丙型肝炎患者随机分为两组,治疗组40例、对照组60例,对照组仅予以聚乙二醇干扰素联合利巴韦林治疗,治疗组在对照组治疗基础上辅以白茅根煎剂治疗。比较各组在治疗过程中快速病毒学应答(RVR)、完全早期病毒学应答(cEVR)、治疗结束时病毒学应答(ETVR)、持续病毒学应答(SVR)、丙氨酸氨基转移酶(ALT)指标及不良反应。结果:治疗组与对照组比较,治疗组ETVR、SVR及血清ALT指标恢复情况均优于对照组(P0.05),治疗组不良反应较对照组轻(P0.05)。结论:白茅根煎剂联合聚乙二醇干扰素、利巴韦林治疗慢性丙型肝炎在提高SVR率、护肝降酶、减轻不良反应方面较单纯应用聚乙二醇干扰素和利巴韦林治疗具有更好的疗效。

Clinical study on treating chronic hepatitis C with the cogongrass rhizome decoction combined with interferon and ribavirin

Objective：To observe the clinical effects and mechanism of cogongrass rhizome decoction combined with PegIFN α-2a（Pegasys） and ribavirin in treating patients with chronic hepatitis C.Meanwhile,the adverse effects of IFN and ribavirin were observed.Methods：Patients with chronic hepatitis C were divided into two groups：treated group（40 cases） and control group（60 cases）,who were all treated with PegIFN α-2a and Ribavirin.Cogongrass rhizome decoction was only applied in the treated group.Rapid virological response（RVR）,complete early virological response（cEVR）,end treated virological response（ETVR）,sustained viral response（SVR）,alanine transaminase（ALT） and adverse effects were observed respectively.Results：After treatment,the incidence of cEVR,SVR and The hepatic functional restoration in the treated group were higher than that of the control group（P0.05）,adverse effects were less severe than those in the control group,the difference was significant（P0.05）.Conclusion：For patients with chronic hepatitis C,Cogongrass rhizome decoction plus PegIFN α-2a and ribavirin therapy are more effective than PegIFN α-2a combining ribavirin therapy in the improvement of SVR,liver protection and release of some adverse effects.