| 电刺激大鼠中缝隐核引起减压反应的机理 |
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| 引用本文： | 邱京欣,顾蕴辉.电刺激大鼠中缝隐核引起减压反应的机理[J].北京大学学报(医学版),1993(1). |
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| 作者姓名： | 邱京欣 顾蕴辉 |
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| 作者单位： | 北京医科大学生理学教研室，北京医科大学生理学教研室 87级基础医学专业学生 |
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| 摘 要： | 电刺激大鼠中缝隐核(RO)引起的减压反应,可被双侧延髓头端腹外侧区(RVL)内预先注射赛庚啶或荷包牡丹碱、静脉注射酚妥拉明或甲基阿托品衰减,但心得安(i,v.)无明显效应。结果提示,该反应可能部分通过RO的5-HT能投射纤维作用于RVL内的GABA能中间神经元,抑制RVL-交感兴奋神经元,使交感缩血管神经活动减弱而实现。心迷走中枢兴奋也参与此反应。
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| 关 键 词： | 中缝隐核 减压反应 赛庚啶 荷包牡丹碱 甲基阿托品 |
MECHANISMS UNDERLYING DEPRESSOR RESPONSE OF NUCLEUS RAPHE OBSCURUS TO ELECTRICAL STIMULATION |
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| Qiu Jingxin,Gu Yunhui.MECHANISMS UNDERLYING DEPRESSOR RESPONSE OF NUCLEUS RAPHE OBSCURUS TO ELECTRICAL STIMULATION[J].Journal of Peking University:Health Sciences,1993(1). |
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| Authors: | Qiu Jingxin Gu Yunhui |
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| Institution: | Qiu Jingxin;Gu Yunhui Department of Physiology |
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| Abstract: | In urethane anesthetized rats, electrical stimulation of the nucleus raphe obscurus (RO) elicited afall in blood pressure. The depressor response could be reduced by preinjection of cyproheptadine (a5HT-antagonist) or bicuculline (a GABA-receptor blocker) into bilateral rostral ventrolateral medulla(RVL); and could also be markedly attenuated by phentolamine or methyl atropine (i.v.), but not bypropranolol (i.v.). The results suggest that RO exerts the depressor response via its 5HT-projectionsacting upon the GABAergic interneurons in RVL, the latter inhibited the RVL-sympathoexcitatoryneurons, causing a decrease in activity of the sympathetic vasoconstrictor nerve; in addition, excitationof the cardiac vagal center is also involved in the depressor response. |
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| Keywords: | Nucleus raphe obscurus Depressor response Cypoheptadine Bicuculline Methyl atropine |
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