葡萄糖氯化钠钾注射液与注射用盐酸头孢吡肟配伍的稳定性

目的研究在室温下葡萄糖氯化钠钾注射液（简称GNK）与注射用盐酸头孢吡肟配伍后的稳定性。方法采用RP-HPLC法测定配伍后注射用盐酸头孢吡肟的含量变化,同时考察配伍溶液的外观、pH值和不溶性微粒的变化。结果在室温下配伍溶液8 h内均无气体或沉淀产生,pH值、不溶性微粒和含量均无明显变化。结论 GNK与注射用盐酸头孢吡肟配伍后8 h稳定,在8 h内可安全应用于临床。

Compatible stability of glucose and sodium potassium chloride injection mixing with cefepime Hydrochloride for injection

Objective To study the stability of glucose and sodium potassium chloride injection(GNK) mixing with cefepime hydrochloride in room temperature.Methods RP-HPLC was applied to determine the content change of cefepime hydrochloride in different time.The pH,quantity of non-soluble particulate and appearance of mixtures were also observed.Results In room temperature the mixtures produced neither gas nor sediment.The pH,quantity of non-soluble particulate and content did not change within 8 hours.Conclusion The mixtures of GNK mixing with cefepime hydrochloride are stable in 8 hours.