| 借助人工神经修复大鼠坐骨神经缺损的实验研究 |
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| 引用本文： | 杨朝阳,蔡青,鲁强,姬曼,王元身,高尔静,刘玉军,李晓光. 借助人工神经修复大鼠坐骨神经缺损的实验研究[J]. 中国康复理论与实践, 2003, 9(3): 182-183 |
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| 作者姓名： | 杨朝阳 蔡青 鲁强 姬曼 王元身 高尔静 刘玉军 李晓光 |
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| 作者单位： | 1. 750004,宁夏银川市,宁夏医学院解剖教研室
2. 100054,北京市,首都医科大学北京神经科学研究所 |
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| 基金项目： | 国家自然科学基金 (准号 :39870 1 91 )资助项目 |
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| 摘 要： | 目的：研究人工神经－壳聚糖复合胶大气层 管修复大鼠坐骨神经15mm缺损的可行性。方法：借助人工神经修复10只大鼠坐骨神经缺损15mm，神经缺损7只为对照组，术后2个月，4个月行免疫组化，Osmium染色、Bodian染色，运动终板的特异染色、WGA－HRP神经示踪及大体观察。结果：术后2个月再生神经修复了坐骨神经的缺损，实验动物未出现排斥反应及明显的炎症反应。结论：人工神经导管对缺损的坐骨神经修复具有良好的桥梁作用和促神经生长的作用。
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| 关 键 词： | 实验研究 人工神经 壳聚糖复合胶原导管 神经再生 大鼠 坐骨神经 |
| 文章编号： | 1006-9771(2003)03-0182-02 |
| 修稿时间： | 2002-12-27 |
Repair sciatic nerve gap of the rats with novel artifical nerve guide |
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| YANG Zhao yang,CAI Qing,LU Qiang,et al.. Repair sciatic nerve gap of the rats with novel artifical nerve guide[J]. Chinese Journal of Rehabilitation Theory and Practice, 2003, 9(3): 182-183 |
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| Authors: | YANG Zhao yang CAI Qing LU Qiang et al. |
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| Affiliation: | YANG Zhao yang,CAI Qing,LU Qiang,et al. Beijing Center for Neural Regeneration and Repairing,Capital University of Medical Science.Beijing 100054,China |
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| Abstract: | ObjectiveTo explore the possibility of repairing sciatic nerve gap of rats with artifical nerve graft.MethodsA novel artifical nerve guide was developed and used to suture the 15 milimeter long right sciatic nerve gap of 10 rats, other 7 rats were the control with the right sciatic nerve gap alone.2 and 4 monthes after operation, immunohistochemistry, Osmium staining, Bodian staining,motor end plate staining,WGA HRP stain tracing have been done to observe the effect of repairing.Results2 months after operations, the sciatic nerve gap were repaired by the regeneration nerve.There was not evident inflammation in the defects.ConclusionsThe artifical nerve graft can induce the nerve to regenerate. |
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| Keywords: | the artifical nerve nerve regeneration sciatic nerve rats |
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