影响冻融胚胎临床结局的因素分析

目的探讨影响冻融胚胎移植结局的相关因素。方法收集我中心2009年570个行冻融胚胎移植周期,回顾性分析患者年龄,移植冻融胚胎质量及数量,内膜厚度对临床妊娠率、种植率、多胎率的影响。结果 Logistic回归分析表明:女方年龄、移植数、移植优质胚胎数与临床妊娠显著相关(P<0.01);多胎与女方年龄和移植数相关(P<0.01;P<0.05)。年龄<35岁的妊娠率(49.4%)明显高于≥35岁的妊娠率(37.9%)(P<0.05);移植2个胚胎的临床妊娠率(49.3%),明显高于移植1个胚胎的临床妊娠率(15.4%)(P<0.05),但与移植3个胚胎的临床妊娠率(50.0%)无差异(P>0.05);移植至少1个优胚组妊娠率(58.0%)较无优胚移植组临床妊娠率(37.5%)显著高(P<0.01)。结论女方年龄及移植的胚胎质量是影响移植后妊娠结局的关键因素。

Analysing the factors that influence the clinical outcomes of the frozen thawed embryo transfer

Objective: To investigate the factors influencing the prognosis of frozen thawed embryo transfer(FET) cycles.Methods: This is a retrospective study analyzing 570 FET cycles.Analysing the influence of the female age,embryo quality,embryo transfer numbers and endometrial thickness on pregnancy rate,implantation rate,ongoing rate,early abortion rate,multiple pregnancy rate.Results:Through logistic regression analysis,we found that the female age,the embryo numbers of transferred and the numbers of high quality embryos transferred,shows close correlation with clinical pregnancy.It appeared a downtrend of pregnancy with the age.The pregnancy rate(49.4%) of patients’ age<35 were higher than patients’ age≥35(37.9%).The quality of embryos,especially the numbers of high quality embryos transferred,shows close correlation with FET outcomes.When two embryos were transferred,the pregnancy rate(49.3%) were higher than one embryo(15.4%).When three embryos were transferred,while the pregnancy rate were similar(50.0%).When≥1 good embryos were transferred,the pregnancy rate(58.0%) were higher than one embryo(37.5%).Conclusion:The female age and the embryo quality of transferred,shows close correlation with FET outcomes.