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| 医药中间体茄尼醇的体外抗菌活性研究 | |
| 引用本文： | 陈保汉,张君,余荷秀,胡庆利.医药中间体茄尼醇的体外抗菌活性研究[J].齐鲁药事,2007,26(9):558-559. |
| 作者姓名： | 陈保汉 张君 余荷秀 胡庆利 |
| 作者单位： | 1. 浙江永宁制药厂,浙江,黄岩,318020 2. 杭州奥默医药技术有限公司,浙江,杭州,310011 3. 临邑县医药公司,山东,临邑,251500 |
| 摘 要： | 目的研究从废弃的烟草叶中提取纯化后的医药中间体茄尼醇,对革兰阴性和革兰阳性菌的体外抗菌活性。方法采用琼脂扩散法和两倍稀释法考察茄尼醇对多种标准菌株和临床分离菌株的抗菌活性。结果与结论茄尼醇对被测菌株中的革兰阴性菌(大肠埃希氏菌和铜绿假单胞菌)和革兰阳性菌(金黄色葡萄球菌和草分枝杆菌)具有显著的抗菌活性,而对枯草杆菌和环状芽孢杆菌活性较弱。 |
| 关 键 词： | 茄尼醇 抗菌活性 烟草叶(茄科烟草属) |
| 文章编号： | 1672-7738（2007）09-0558-02 |
In Vitro Study on the Antibacterial Activities of a Medicinal Intermediate, Solanesol |
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| CHEN Bao-han,ZHANG Jun,YU He-xiu,HU Qing-li.In Vitro Study on the Antibacterial Activities of a Medicinal Intermediate, Solanesol[J].qilu pharmaceutical affairs,2007,26(9):558-559. | |
| Authors: | CHEN Bao-han ZHANG Jun YU He-xiu HU Qing-li |
| Institution: | 1.Zhejiang Yongning Pharmaceutical Factory, Huangyan 318020;2. Hangzhou Aome Medical Technology Company Limited, Hangzhou 310011 ;3. linyi county medicine company,Linyi 251500 |
| Abstract: | OBJECTIVE Solanesol,purified from abandoned tobacco leaf,is an important medicinal intermediate.Our aim of this study was to observe the antibacterial effect of solanesol against the gram-negative and gram-positive bacteria.METHODS Two classic methods,broth dilution and two-fold dilution,were employed to examine the activities of solanesol on several standard strains and those collected from clinical patients.RESULTS and CONCLUTION Solanesol demonstrated significant antibacterial activities against all of the gram-negative(Escherichia coli and Pseudomonas aeruginosa)and most of the gram-positive bacteria(Staphylococcus aureus and Mycobacterium phlei)tested.Low antibacterial effects were shown for the two strains,Bacillus subtilis and Bacillus circulans. |
| Keywords: | Solanesol antibacterial activity tobacco leaves(Nicotiana tabacum L) |
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