鼓膜置管联合药物灌注治疗难治性分泌性中耳炎的疗效分析

目的观察鼓膜切开置管联合药物灌注治疗难治性分泌性中耳炎的疗效。方法将2011年11月～2012年4月入住郑州大学第一附属医院及2011年6月～2012年10月入住商丘市第一人民医院的符合难治性分泌性中耳炎诊断的患者109例纳入临床研究,随机分为实验组和对照组,实验组为54例,对照组为55例,实验组采用鼓膜切开置管加药物灌注治疗（地塞米松磷酸钠注射液＋注射用糜蛋白酶）,对照组采用单纯鼓膜切开置管治疗;进行治疗前以及治疗后1个月、12个月时耳的言语频率平均听阈检测,对比治疗前及治疗后12个月的峰压值、静态声顺值;观察两组患者的总体治疗有效率。结果实验组患者的总体治疗有效率达85.19%,显著高于对照组65.45%;实验组患者治疗前后的耳峰压值、静态声顺值改善显著好于对照组;实验组患者治疗1个月、12个月后的言语频率平均听阈改善情况显著好于对照组。结论鼓膜切开置管加药物灌注治疗治疗难治性分泌性中耳炎的疗效显著。

Investigate study of curative effect of tympanostomy tube combined with drug perfusion in the treatment of refractory secretory otitis media

OBJECTIVE To observe the curative effect of tympanostomy tube combined with drug perfusion in the treatment of refractory secretory otitis media. METHODS 109 cases of refractory secretory otitis media patients were included from the first affiliated hospital of Zhengzhou university（November 2011-April 2012） and Shangqiu first people＇s hospital（June 2011-October 2012）. All patients were treated by myringotomy tube and were divided into experimental group（myringotomy tube combined with drug perfusion） and control group（myringotomy tube only） randomly. General treatment efficiency of were observed.Speech frequency average hearing threshold were compared between the two groups before treatment and 1 months, 12 months after treatment.Peak pressure, static compliance value of ears were compared between the two groups before treatment and 12 months after treatment. RESULTS The total effective rate of experimental group was 85.19%, significantly higher than that of control group 65.45%; the peak pressure improvement of experimental group patients in treatment was significantly higher than control group;the static compliance improvement of experimental group was significantly higher than that of the control group;the speech frequency hearing threshold improvement of experimental group at 1 months and 12 months after treatment was significantly higher than that of the control group. CONCLUSION The curative effect of tympanic drug perfusion in the treatment of refractory secretory otitis media was significant.