浙江省肿瘤登记地区鼻咽癌发病与死亡现状及趋势分析

目的　研究浙江省肿瘤登记地区2000～2009年鼻咽癌发病与死亡的流行状况及趋势。方法　鼻咽癌发病与死亡数据来源于浙江省6个肿瘤登记地区，并经浙江省癌症中心审核、整理和统计分析，计算粗率、标化率及变化趋势。结果　2000～2009年浙江省肿瘤登记地区鼻咽癌粗发病率和粗死亡率分别为4.47/10万和.82/10万，中标率分别为2.64/10万和0.95/10万，占全部癌症新发病例和死亡病例的1.65%和1.15%。鼻咽癌年龄别发病率在20岁之前处于较低水平，在60～64岁组达到高峰，为10.90/10万，年龄别死亡率在35岁之前处于较低水平，在80～84岁组达到高峰，为8.76/10万。2000～2009年浙江省鼻咽癌发病率呈现波动增长趋势，2002年最低为3.26/10万，2005年最高为4.88/10万，年度变化百分比（APC）为4.04%（95%CI 为1.08%～7.08%），鼻咽癌死亡率则呈现波动下降趋势。结论浙江省鼻咽癌发病率介于高发区与低发区之间，且发病率呈现增长趋势，提示应进一步开展分析流行病学调查，研究其病因和防治对策。

Analysis of the status and trend of nasopharyngeal carcinoma incidence and mortality in cancer registries of zhejiang province

OBJECTIVE To investig te epidemiology characteristics and trends of nasopharyngeal carcinoma（NPC） incidence and mortality in Zhejiang cancer registration areas from 2000 to 2009. METHODS Cancer registration data were collected from 6 cancer registries of Zhejiang province. The data were checked, sorted and analyzed by Zhejiang Cancer Center. The crude rate, proportions, age standardized rates, cumulate rates, cut rates, age-specific rates and Annual Percentage Change（95%CI） of NPC were calculated. RESULTS The crude incidence rate and the mortality rate of NPC were 4.47/100,000 and 1.82/100,000 between 2000 and 2009 in Zhejiang, the age-standardized by Chinese population were 2.64/100,000 and 0.95/100,000, accounted for 1.65% of new cancer cases and 1.15% of all deaths cases. Age-specific incidence of NPC remained low before 20 years old, and peaked at 60-64 years old age group（10.09/100,000）. Agespecific mortality of NPC remained low before 35 years old, and peaked at 80～84 years old age group（8.76/100,000）. The annual NPC incidence rate increased fluctuatedly between 2000 and 2009 in Zhejiang, stayed the lowest level in 2002（3.26/100,000） and reached the highest level in 2005（4.88/100,000）, the Annual Percent Change（APC） is 4.04%（95%CI=1.08%-7.08%, statistical significance）, meanwhile, the annual NPC mortality rate declined f luctuatedly. CONCLUSION The incidence of NPC in Zhejiang was between the high and low incidence areas and had a growth trend,which indicates that further epidemiological study and prevention for NPC should be strengthened.