血红素氧合酶-1和抗血管生长因子与2型糖尿病视网膜病变的相关性研究

目的 探讨血红素氧合酶-1（HO-1）及抗血管生长因子——Avastin与DR的相关性. 方法 选取T2DM无视网膜病变组（NDR） 55例,背景期DR组（BDR） 53例,增殖期DR组（PDR） 56例,老年单纯白内障对照组（Con） 50例.采用ELISA对血液及房水的HO-1、Avastin进行检测. 结果 与Con组比较,BDR组和PDR组血液及房水HO-1[血：（17.47±5.75）、（19.25±6.95） vs（15.32±3.56）ng/ml;房水：（0.77±0.45）、（0.89±0.36）vs（0.52±0.47） ng/ml]、Avastin[血：（5.69±4.11）、（7.32±3.45）vs（1.49±0.86） ng/ml;房水：（32.58±18.74）、（55.12±32.17）vs（7.85±6.73） pg/ml]均升高（P＜0.01）,且随DR严重程度升高更明显. 结论 HO-1、Avastin与DR相关,可能参与了DR的发生发展过程.

Correlation of heme oxygenase-1 and anti-vascular growth factor antibody with type 2 diabetic retinopathy

Objective To explore the correlation of heine oxygenase-1 （HO-1） and anti-vascular growth factor （Avastin） with diabetic retinopathy （DR）. Methods 55 cases of patients of type 2 diabetes without retinopathy （NDR group）, 53 cases of diabetic retinopathy （DR） in background phase, and 56 cases of diabetic retinopathy （DR） in proliferative phase were （PDR group） selected. Meanwhile, 50 cases of elderly patients suffering from cataract without DR were selected as the control group. HO-1 and Avastin of blood and aqueous humor were detected by enzyme~linked immunosorbent assay. Results Compared with the control group, BDR and PDR group showed that in both blood and aqueous humor the HO-1 [blood= （17.47±5.75）, （19.25±6.95） vs （15.32±3.56） ng/ml;aqueous humor： （0. 77±0.45）, （0.89±0.36） vs （0.52±0.47） ng/ml] and Avastin [blood： （5.69±4. 11）,（7.32±3.45） vs （1.49±0.86） ng/ml; aqueous humor： （32.58± 18. 74）, （55.12±32.17） vs （7.85±32.17） pg/ml] were increased （P〈0.01）, and they were more significant with the increase of the severity degree of DR. Conclusion HO-1 and Avastin are correlated with diabetic retinopathy and might be involved in the development process of DR.