尼麦角林治疗血管性认知功能障碍疗效观察

目的：探讨尼麦角林治疗血管性认知功能障碍的疗效。方法选取血管性认知功能障碍患者87例，随机分为治疗组（44例）和对照组（43例），对照组给予抗动脉粥样硬化治疗，治疗组在此基础上服用尼麦角林，疗程为12周，通过日常生活能力量表（ADL）、简易智力状态检查表（MMSE）及韦克斯勒记忆量表（WMS）进行评分，评价两组疗效。结果治疗12周后，两组患者的ADL评分均明显下降，MMSE及WMS评分均明显升高，与治疗前比较差异均有统计学意义（P均＜0.05），其中治疗组ADL、MMSE及WMS评分改善情况均明显优于对照组（P＜0.05），且治疗过程中未发现有明显不良反应。结论尼麦角林治疗血管性认知功能障碍有明显的疗效。

Effect of nicergoline in treatment of vascular cognitive impairment

Objective To investigate the effect of nicergoline in treatment of vascular cognitive im-pairment. Methods Eighty-seven cases of vascular cognitive impairment were divided into the control group （n=44）and the treatment group （n=43）randomly. Two groups both acceptted treatment of atherosclerosis, the patients in treatment group were additionally administered with nicergoline for 1 2 weeks,then the effect was evaluated by activities of daily living sacle （ADL）、mini-mental state examination （MMSE）and wechsler memory scale （WMS）in both groups. Results After 1 2 weeks,ADL scores were significantly decreased,and MMSE and WMS scores were significantly increased compared with pre-treatment in both two groups （P＆lt;0.05 ）. And the results of ADL,MMSE and WMS in the treatment group were better than those of the control group （P＆lt;0.05 ）. Obvious adverse reactions were not found during the treatment. Conclusions Nicergoline shows an obvious effect on vascular cognitive impairment.