25-羟维生素D水平与糖尿病视网膜病变的关系

目的探究血清25-羟维生素D（25-OHD）水平与糖尿病视网膜病变（DR）发生发展的关系。方法研究对象为553例2型糖尿病患者（糖尿病组，DM组）和62名健康人（健康对照组，NDM组），DM组按眼底变化情况分为无糖尿病视网膜病变组（NDR组）、背景期视网膜病变组（NPDR组）和增殖期视网膜病变组（PDR组）。检查并记录所有参与者的眼底变化及血清25-OHD水平、血压和糖化血红蛋白（HbAlc）等指标。结果DR组血清25-OHD水平与NDR组相比，差异有统计学意义（P〈0．05），多元Logistic回归分析显示25-OHD是DR的影响因素。结论较高水平的25-OHD可能是DR的一种保护性因素。

Relationship between Serum 25 - hydroxyvitamin D Levels and Diabetic Retinopathy.

Objective To explore the relationships between the serum levels of 25 - hydroxyvitamin D （25 - OHD） and the devel- opment of diabetic retinopathy. Methods 553 hospitalized patients with type 2 diabetes in our hospital were divided into three groups ac- cording to the changes in the fundus of the patients：the first group without diabetic retinopathy （NDR group, n =179） , the background retinopathy group （ NPDR group, n = 374） and the proliferative retinopathy group （ PDR group, n = 105）. Sixty - two persons without di- abetes were divided to the control group （NDM group, n = 62）. All the patient＇s fundus changes were examined and recorded, and the se- rum levels of 25 - OHD, blood pressure and glycosylated hemoglobin （ HbA1 c） were measured. Results The serum 25 - OHD levels in NPDR group and PDR group were significantly higher compared with this of the NDR group, and the differences were statistically signifi- cant （P 〈 0.05）. Multivariate logistic regression analysis showed that 25 - OHD was an influencing factor for the development of DR. Conclusion Higher levels of 25 - OHD may be a protective factor of DR.