促排卵天数不能预测长方案IVF-ET妊娠结局

目的分析长方案中促排卵天数对试管婴儿妊娠结局的影响。方法回顾性分析自2010年4月-2012年6月在本中心行IVF-ET治疗的长方案周期共599例。将所有的周期按促排卵天数分为〈10天、10-12天、〉12天3个组，比较各组间总的Gn（gonadotropin）使用量、成熟卵泡数、取卵个数、授精卵个数、优质胚胎数、原发不孕率和临床妊娠率。评估促排卵天数对这些参数的影响。将卵巢功能好的周期再次分组，分析促排卵天数对以上这些参数的影响。结果对总的周期来说，3组间的妊娠率分别为28．6％、31．5％、29．7％，3组间比较U差异无统计学意义（P〉0．05），然而，3组间Gn使用量、卯泡数量随着促排卵时间的延长而增多（P〈0．05）。重新分组后，3个促排卵天数问的Gn使用量、成熟卵泡数、取卵个数、受精卵个数、优质胚胎数、原发不孕率和临床妊娠率等均无统计学差异（P〉0．05）。结论促排卵天数不能预测长方案IVF-ET的妊娠结局，增加促排卵天数能增加卵泡数量，但是不能增加成熟卵泡数量，并没有改善临床妊娠结局，提示为获取更多卵泡而延长促排卯时间的做法是不经济的，且费时费力。

No Predict Value of the Duration of Gonadotropin on Outcome of In - vitro Fertilization Treatment.

Objective To examine whether the duration of gonadotropin impactes IVF outcome of long protocols. Methods A retro- spective analysis of 599 long protocols IVF - ET cycles at our institution between April 2010 and June 2012 was performed. All the proto- cols were categorized into three groups which were 〈 10 days, 10 - 12days , 〉 12days. Parameters among the three groups assessed were total ampoules of gonadotropins, the number of mature eggs,the number of eggs retrieved, the number of fertilization embryos,the number of high - quality embryos, primary infertility rates and clinical pregnancy rates. Whether the duration of gonadotropin stimulation affeetes these parameters was evaluate. Results For all the cycles,the duration of stimulation cannot predict IVF - ET outcome. The clinical pregnancy in the three groups were 28.6% ,31.5% ,29.7% , showed no significant difference（ P 〉 0.05 ）. However, the total Gn consuming and the retrieved oocytes was more in the longer ovary stimulation cycles （ P 〈 0.05）. After regroup the patient who had good ovary function, we found all the parameters were the same in three groups（ P 〉 0.05）. Conclusion The duration of gonadotropin stimulation cannot predict IVF - ET outcome in the long protocal. Plonger the ovary stimulation can get more unmature oocytes which can＇t improve the clinical out- come. It implys that it＇s uneconomical and time - wasted to plong the stimulation duration in order to get more ooeyte in one cycle.