血清γ谷氨酰转肽酶与BMI的相关性研究

目的：探讨血清γ-谷氨酰转肽酶（GGT）与BMI水平的关系。方法采用横断面研究法对某轻体力劳动单位职工进行问卷调查、体格检查、生化检测等，对资料完整的172名职工的数据进行分析，比较不同BMI水平、不同性别及不同GGT水平组别间一般资料的差异，采用单因素方差分析、Pearson相关分析及多元逐步回归分析探讨GGT与BMI的相关性。结果体质量过低组、正常体质量组、超体质量组、肥胖组4组间GGT水平比较差异有统计学意义（P＜0.05）；男性4个GGT四分位组间BMI、腹围、心率、舒张压、ALT、AST、碱性磷酸酶（ALP）比较差异有统计学意义（P＜0.05）；女性4个GGT四分位组间ALT、AST、ALP、HDL-C、甘油三酯比较差异有统计学意义（P＜0.05）；Pearson 相关分析显示，男性组 GGT 水平与 BMI、腹围、心率、肝右斜径、ALT、AST、ALP呈正相关，女性组GGT水平与BMI、腹围、收缩压、舒张压、ALT、AST、ALP、血肌酐、甘油三酯呈正相关，与HDL-C呈负相关。多元逐步回归分析提示GGT可以显著影响BMI及腹围；调整了性别、年龄、GGT、肝右斜径、ALT、AST、ALP、血肌酐、HDL-C、LDL-C、甘油三酯、空腹血糖等指标之后，GGT与BMI独立相关。结论血清GGT水平的上升与BMI水平存在显著且独立的相关性。

Correlation research on gamma-glutamyltransferase and body mass index

Objective To explore the relationship between serum gamma-glutamyltransferase （GGT）and body mass index （BMI）. Methods All subjects of this cross-sectional study engaged in light manual labor. The study was conducted by questionnaire survey,anthropometric measurements and biochemical examination. And then 172 subjects with complete data were enrolled and divided into different sub-groups ac-cording to BMI,gender and GGT. The association between serum GGT and BMI was analyzed by one-way anal-ysis of variance,Pearson correlation analysis and multiple stepwise regression analysis. Results GGT levels in 4 BMI sub-groups were significantly different （P〈0.05）. In male,from GGT quartile 1 to quartile 4,the differences of BMI,waist circumference,heart rate,diastolic blood pressure,alanine aminotransferase,aspar-tate aminotransferase,alkaline phosphatase were significant,while in female,the differences of alanine amin-otransferase,aspartate aminotransferase,alkaline phosphatase,high density lipoprotein cholesterol,triglyceride were significant （P〈0.05 ）. Pearson correlation analysis showed that GGT in male was positively related with BMI,waist circumference,heart rate,the oblique diameter of right lobe of liver measured by ultrasound,ala-nine aminotransferase,aspartate aminotransferase,alkaline phosphatase. In female,GGT was positively related with BMI,waist circumference,systolic blood pressure,diastolic blood pressure,alanine aminotransferase,as-partate aminotransferase,alkaline phosphatase,serum creatinine,triglyceride,but negatively related with high density lipoprotein cholesterol. Multiple stepwise regression analysis revealed that increased serum GGT level had a significant association with BMI and waist circumference. After adjusting for age,gender,waist circum-ference,heart rate,blood pressure,the oblique diameter of right lobe of liver,blood lipid,fasting glucose lev-el,alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase and serum creatinine,GGT was independently related with BMI. Conclusion There is a significantly independent correlation between serum GGT and BMI.