气管血管球瘤6例并文献复习

目的分析气管血管球瘤（glomustuillor，GT）的临床病理特征、诊断与鉴别诊断、治疗及预后。方法对6例气管GT的临床病理和免疫组织化学特征进行回顾性分析，并结合相关文献复习。结果气管GT缺乏特征性临床表现，纤维支气管镜及CT检查示气管内新生物。纤维支气管镜下，肿瘤位于气管黏膜下组织，无包膜，内有大量扩张的薄壁血管。肿瘤细胞围绕血管成片分布，瘤细胞圆形或卵圆形，大小一致，胞质淡染嗜酸性，核仁不明显，未见核分裂象。免疫组织化学显示：Vimentin、SMA均阳性。结论发生于气管的GT非常罕见，由于其缺乏特征性的临床表现及镜下特点而极易误诊为类癌，确诊需在HE形态学的基础上，结合免疫组织化学染色进行诊断及鉴别诊断。

Report of Six Cases of Trachea Glomus Tumor and Review of the Literature.

Objective To analysis the clinieopathological features, diagnosis and differential diagnosis, treatment and prognosis of trachea glomus tumor（GT）. Methods The elinicopathological and immunohistochemistry expression were retrospectively analyzed in six cases of GT with the review of the literatures. Results Trachea glomus tumor had no characteristic clinical manifestations. Fiberoptic bronchoscopy and CT examination displaed that there was space -occupying lesions in trachea. Microscopically, tumors were located in the tracheal submucosal tissue, but noneneapsulated. GT had large number of dilated thin - wailed blood vessels. Tumor ceils were round or oval,and pale eosinophilic cytoplasm, nucleolus were not obvious. Mitotic figures were rare,and growed around blood vessels. Immuno- histochemically, the tumor cells were positive for vimentin and SMA. Conclusion GT is rare in trachea sites. It may be misdiagnosed as carcinoid due to the lack of characteristic clinical manifestations and endoscopic characteristics. Diagnosis and differential diagnosis should be made in combination with immunohistochemical staining and histologic examination.