| 支气管哮喘相关基因CHI3L1的研究进展 |
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| 引用本文： | 王洪霞,刘春涛. 支气管哮喘相关基因CHI3L1的研究进展[J]. 中华哮喘杂志(电子版), 2012, 6(3): 183-186 |
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| 作者姓名： | 王洪霞 刘春涛 |
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| 作者单位： | 四川大学华西医院呼吸内科,成都,610041 |
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| 摘 要： | 支气管哮喘（简称哮喘）是一种具有明显遗传倾向的变态反应性疾病，多年来对哮喘相关基因进行了大量研究，但尚未取得突破性进展。CHI3L1基因是一种新发现的哮喘相关基因，编码一种几丁质酶样蛋白YKL-40。本文对CHI3L1基因、YKL-40的分布、功能及其可能参与哮喘发病的机制作一综述。
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| 关 键 词： | CHI3L1 YKL-40 哮喘 基因 |
Research development of CHI3L1:an bronchial asthma related gene |
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| WANG Hong-xia , LIU Chun-tao. Research development of CHI3L1:an bronchial asthma related gene[J]. Chinese Journal of Asthma(Electronic Version), 2012, 6(3): 183-186 |
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| Authors: | WANG Hong-xia LIU Chun-tao |
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| Affiliation: | .Department of Respiratory Medicine,West China Hospital,Sichuan University,Chengdu 610041,China |
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| Abstract: | Bronchial asthma(asthma) is an atopy disease with significant genetic predisposition.There are extensive research on asthma related genes for many years,but has not yet made a breakthrough.CHI3L1 gene is a new discovery of asthma gene which encodes a chitinase-like protein YKL-40.This article reviews the distribution,function and mechanisms may be involved in the pathogenesis of asthma of CHI3L1 gene and YKL-40. |
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| Keywords: | CHI3L1 YKL-40 Asthma Gene |
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