|
|||||
|
|
Lonicera japonica Thunb.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine |
|
| Authors: | Shang Xiaofei Pan Hu Li Maoxing Miao Xiaolou Ding Hong |
| Affiliation: | a Engineering & Technology Center of Traditional Chinese Veterinary Medicine of Gansu, Key Laboratory of Veterinary Pharmaceutics Discovery, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, PR China b Department of Pharmacy, Lanzhou General Hospital of PLA, Key Laboratory of the Prevention and Treatment for Injury in Plateau of PLA, Lanzhou 730050, PR China c Key Laboratory of Chemistry and Quality for Traditional Chinese Medicines of the College of Gansu Province, Gansu College of Traditional Chinese Medicine, Lanzhou 730000, PR China d Northwest Normal University, Lanzhou 730050, PR China |
| Abstract: | Ethnopharmacological relevanceLonicera japonica Thunb. (Caprifoliaceae), a widely used traditional Chinese medicine, was known as Jin Yin Hua (Chinese: ), Ren Dong and Japanese honeysuckle. It was taken to treat the exopathogenic wind-heat, epidemic febrile diseases, sores, carbuncles and some infectious diseases. At the same time, Lonicera japonica could be used as healthy food, cosmetics, ornamental groundcover, and so on.Aim of the reviewThe present paper reviewed the ethnopharmacology, the biological activities, toxicology and phytochemistry of Lonicera japonica.Materials and methodsInformation on Lonicera japonica was gathered via the Internet (using Google Scholar, Baidu Scholar, Elsevier, ACS, Medline Plus, CNKI and Web of Science) and libraries. Additionally, information also was obtained from some local books and brilliant scholars on ethnopharmacology.ResultsMore than 140 chemical compounds have been isolated, and the main compositions are essential oils, organic acids and flavones, etc. Lonicera japonica and its active principles possess wide pharmacological actions, such as anti-inflammatory, antibacterial, antiviral, antioxidative and hepatoprotective activities.ConclusionsAs an important traditional Chinese medicine, further studies on Lonicera japonica can lead to the development of new drugs and therapeutics for various diseases, and how to utilize it better should be paid more attentions. |
| Keywords: | ACV, acyclovir AIV, avian influenza virus ALT, alanine transarninase AST, aspartate amino transferase CAT, catalase Cd, cadmium CGN, carrageenan COX, cycloxygenase ConA, concanavalin A CPE, cytopathologic effect DAD, diode-array detection DPPH, 1,1-diphenyl-2-picrylhydrazyl ELSD, evaporative light scattering detectors EtOAc, ethyl acetate ERK, extracellular signal-regulated kinase GC-MS, gas chromatography-mass spectrometry GSH, glutathione HDL-C, high density lipoprotein cholesterin HIV-1, human immunodeficiency virus-1 HPLC, high performance liquid chromatography HSV, Herpes simplex virus HUVEC, Human Umbilical Vein Endothelial Cells IC50, 50% inhibition concentration JNK, Jun nuclear kinase LED, Least Effective Dose Lonicera japonica, Lonicera japonica Thunb. LPS, lipopolysaccharide MAPK, mitogen activated protein kinase MDA, malondialdehyde MEC, minimum effective concentration MeOH, methyl alcohol MIC, minimum inhibitory concentration MPO, myeloperoxidase MTT, methyl thiazolyl tetrazolium MUFA, monounsaturated fatty acid NDV, newcastle disease virus NO, nitric oxide PAPR2, proteinase-activated receptor 2 PDT, photodynamic therapy PMNs, polymorphonuclear leukocytes PUFA, polyunsaturated fatty acid ROS, reactive oxygen species RSV, respiratory syncytial virus SARS coronavirus, severe acute respiratory syndromes coronavirus SFA, saturated fatty acid SI, selectivity index SOD, superoxide dismutase TCM, traditional Chinese medicine TEAC, Trolox equivalent antioxidant capacity TI, therapeutic index TLC, thin layer chromatography TNF-α, tumor necrosis factor-α TOF-MS, time-of-flight mass spectrometry |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |