Neurodevelopment of Infants with Prenatal Exposure to Polybrominated Diphenyl Ethers |
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Authors: | Cherng-Gueih Shy Huei-Lin Huang Gou-Ping Chang-Chien How-Ran Chao Tsui-Chun Tsou |
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Affiliation: | Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Pingtung County, 907, Taiwan. |
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Abstract: | The study aimed to examine the impact of prenatal exposure to polybrominated diphenyl ethers (PBDEs) on infant neurodevelopment. PBDEs levels in 36 cord blood samples were analyzed with a high-resolution-gas-chromatograph/high-resolution-mass-spectrometer and infant neurodevelopment was assessed using the Bayley Scales of Infant and Toddler Development, Third Edition. The mean and median of Σ(11)PBDEs were 6.63 and 4.63?ng/g lipid, respectively. As compared to the lower PBDEs group (Σ(11)PBDEs?4.63?ng/g lipid), the higher PBDEs group (Σ(11)PBDEs?>?4.63?ng/g lipid) had a significantly higher actual odds ratio (OR?=?1.13, p?0.05) of the cognition score as well as a lower odds ratio (OR?=?0.904, p?0.01) of the adaptive behavior score, suggesting that prenatal PBDEs exposure may potentially affect infant neurodevelopment. |
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