Latent tuberculosis infection in a military setting diagnosed by whole-blood interferon-gamma assay |
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Authors: | Choi Chang-Min Hwang Seung Sik Lee Chang-Hoon Lee Hye Won Kang Cheol-In Kim Chang-Hoon Han Sung Koo Shim Young-Soo Yim Jae-Joon |
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Affiliation: | Department of Internal Medicine, Armed Forces Capital Hospital, Seoul, Korea. |
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Abstract: | BACKGROUND AND OBJECTIVES: Rapid and accurate diagnosis of latent tuberculosis infection (LTBI) is crucial in military settings. This study aimed to detect the prevalence of LTBI using a whole-blood interferon-gamma assay based on Mycobacterium tuberculosis-specific antigens, and to identify risk factors for LTBI among military personnel in contact with patients with active pulmonary TB. METHODS: This prospective study investigated contacts in military camps in South Korea of soldiers with active pulmonary TB. The whole-blood interferon-gamma assay was performed using QuantiFERON TB-Gold. RESULTS: Among the 175 contacts, 25 (14.3%) showed positive results to the assay. Long duration of exposure (OR 2.83; 95% CI: 1.63-4.91), laryngeal TB (OR 6.04; 95% CI: 1.54-23.67) and intensive exposure (OR 5.13; 95% CI: 1.63-16.12) were associated with a positive result. CONCLUSIONS: A relatively small number of TB contacts in a military setting had LTBI. |
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Keywords: | diagnosis latent tuberculosis infection multidrug-resistant tuberculosis whole-blood interferon-γ assay |
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