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Noscapine inhibits tumor growth in TMZ-resistant gliomas |
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| Authors: | Jhaveri Niyati Cho Heeyeon Torres Shering Wang Weijun Schönthal Axel H Petasis Nicos A Louie Stan G Hofman Florence M Chen Thomas C |
| Affiliation: | a Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States b Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States c Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States d Department of Chemistry, College of Letters, Arts & Sciences, University of Southern California, Los Angeles, CA, United States e Department of Clinical Pharmacy and Pharmaceutical Economics and Policy, School of Pharmacy, University of Southern California, Los Angeles, CA, United States |
| Abstract: | Noscapine, a common oral antitussive agent, has been shown to have potent antitumor activity in a variety of cancers. Treatment of glioblastoma multiforme (GBM) with temozolomide (TMZ), its current standard of care, is problematic because the tumor generally recurs and is then resistant to this drug. We therefore investigated the effects of noscapine on human TMZ-resistant GBM tumors. We found that noscapine significantly decreased TMZ-resistant glioma cell growth and invasion. Using the intracranial xenograft model, we showed that noscapine increased survival of animals with TMZ-resistant gliomas. Thus noscapine can provide an alternative therapeutic approach for the treatment of TMZ-resistant gliomas. |
| Keywords: | Glioma Noscapine Temozolomide-resistance Invasion Brain tumors |
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