Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo |
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Authors: | Park Hyun-Joo Kim Su-Ryun Kim Mi-Kyoung Choi Kyu-Sil Jang Hye-Ock Yun Il Bae Soo-Kyung Bae Moon-Kyoung |
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Affiliation: | a School of Dentistry, Pusan National University, Yangsan 626-870, South Korea b Molecular & Cellular Imaging Center, Samsung Biomedical Research Institute, Sungkyunkwan University, School of Medicine, Seoul 136-710, South Korea |
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Abstract: | Neuromedin B (NMB), a member of the mammalian bombesin-like peptide family, and its receptor were aberrantly expressed in vascularized solid tumors. Here, the NMB receptor (NMB-R) antagonist PD168368 specifically inhibited both NMB-induced in vivo and in vitro angiogenesis. In addition, PD168368 showed growth inhibitory effects on MDA-MB-231 breast cancer cells by inducing cell cycle arrest and apoptosis. Furthermore, PD168368 effectively suppressed tumor growth in a xenograft model of breast tumor in vivo. Overall, NMB-R antagonist exhibited a significant antitumor activity by simultaneously inhibiting neovascularization and cancer cell growth, thereby suggesting that NMB-R could be a potential therapeutic target for cancer treatment. |
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Keywords: | Neuromedin B receptor antagonist Vascular endothelial cells Angiogenesis Breast cancer cells Tumor growth |
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