Chemotherapy-induced neutropenia in lung cancer patients: the role of antibiotic prophylaxis |
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Authors: | Kouranos Vasileios Dimopoulos George Vassias Antonios Syrigos Kostas N |
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Affiliation: | a Oncology Unit, Sotiria General Hospital, Athens School of Medicine, Building Z, Mesogion 152, 11527 Athens, Greece b 2nd Department of Critical Care, Attikon University Hospital, Athens School of Medicine, Rimini 1, Haidari, 12462 Athens, Greece |
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Abstract: | Chemotherapy-induced neutropenia can cause fatal bacterial infections. Colony-stimulating factors (CSFs) are usually recommended as prophylaxis, while routine use of prophylactic antibiotics remains controversial. Based on our literature search in PubMed, quinolones and trimethoprim/sulfamethoxazole were the most frequently used prophylaxis, while CSFs were administered in 22.1% of patients. Lung cancer patients who received prophylactic antibiotics exhibited significantly fewer episodes of febrile neutropenia, fewer documented infections as well as shorter duration of related hospitalisations. Prophylactic use of wide spectrum antibiotics seems effective and should be considered as an alternative strategy in the prevention of chemotherapy-induced neutropenia in lung cancer patients. |
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Keywords: | Antibiotic Infection Lung cancer Neutropenia Prophylaxis |
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