Evaluation of treatment response for breast cancer:are we entering the era of "biological complete remission"? |
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作者姓名: | Li Bian Tao Wang Yi Liu Hui-Qiang Zhang Jin-Jie Song Shao-Hua Zhang Shi-Kai Wu San-Tai Song Ze-Fei Jiang |
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作者单位: | Department of Breast Cancer,Affiliated Hospital of Academy of Military Medical Sciences;Laboratory of Oncology,Affiliated Hospital of Academy of Military Medical Sciences |
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基金项目: | supported by the department of pathology and the PET/CT center of Affiliated Hospital of Academy of Military Medical Sciences |
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摘 要: | Breast cancer is one of the most common malignancies in women.The post-operative recurrence and metastasis are the leading causes of breast cancer-related mortality.In this study,we tried to explore the role of circulating tumor cell(CTC) detection combination PET/CT technology evaluating the prognosis and treatment response of patients with breast cancer;meanwhile,we attempted to assess the concept of "biological complete remission"(bCR) in this regard.A 56-year-old patient with breast cancer(T2N1M1,stage IV left breast cancer,with metastasis to axillary lymph nodes and lungs) received 6 cycles of salvage treatment with albumin-bound paclitaxel plus capecitabine and trastuzumab.Then,she underwent CTC detection and PET/CT for efficacy evaluation.CTC detection combination PET/CT is useful for the evaluation of the biological efficacy of therapies for breast cancer.The bCR of the patient appeared earlier than the conventional clinical imaging complete remission and promised the histological(pathological) complete remission.The integrated application of the concepts including bCR,imageological CR,and histological CR can achieve the early and accurate assessment of biological therapeutic reponse and prognosis of breast cancer.
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关 键 词: | Breast cancer circulating tumor cell PET/CT biological complete remission |
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