肺部孤立性结节或肿块的MSCT灌注参数与病理对照分析

目的 探讨16层螺旋CT灌注参数对肺部孤立性结节或肿块的诊断价值.方法 利用GE lightspeed ultra 16层螺旋CT对66例(1.5～6.0 cm)肺部孤立性结节或肿块进行灌注成像,将符合研究条件的57例(男性42例,女性15例)的灌注参数与病理结果进行对照分析.结果 周围型肺癌(恶性组)32例;活动性炎性结节或肿块(炎性组)8例;其他良性结节或肿块(良性组)17例.恶性和炎性组的BF、BV、PS值均明显高于良性组(P＜0.01),恶性组PS值明显高于炎性组(P＜0.01),BF、BV值在恶性与炎性组间没有统计学差异(P＞0.05);恶性组的MTT值明显高于良性组(P＜0.01),但是恶性与炎性之间和炎性与良性组之间MTT值无统计学差异(P＞0.05).结论 CT灌注参数可定量地反映肺部孤立性结节或肿块的血流灌注状态,有助于其诊断与鉴别诊断.

Comparative study between outcomes perfusion parameters of multi-slice computed tomography and pathological of lung solitary nodule or mass

Objective To assess the value of the 16-slice spiral CT perfusion parameters in diagnosing the solitary nodule or mass in the lungs. Methods Sixty-six patients with solitary nodule or mass in the lungs were performed 16-slice spiral CT perfusion scanning with GE Light-Speed ultra 16 CT scanner(1.5-6.0 cm). The CT perfusion parameters and the histological/cytological results were analyzed comparatively. Fifty-seven cases (42 men,15 women) were subjected in this study.Results Histology/cytology revealed 32 peripheral lung cancers,8 inflammatory solitary nodules or masses,and the other benign solitary nodule or mass were 17 cases. Blood flow(BF),blood volume (BV) and permeability surface (PS) from both the malignant and the inflammatory cases were significantly higher than those of benign cases (P<0.01). PS was significantly higher in malignant cases than inflammatory ones(P<0.01). No statistically significant differences in BF and BV were found between malignant and inflammatory patients (P>0.05). Mean transit time (MTT) was apparently higher in malignant cases than benign ones(P<0.01),but there was no statistically significant difference in MTT between malignant and inflammatory cases or between inflammatory and benign cases(P>0.05). Conclusion Perfusion parameters of multi-slice computed tomography can provide the quantitative perfusion information of the peripheral solitary nodule or mass in the lung,which is helpful in the diagnosis and discrimination.