p27和cyclin E蛋白表达与膀胱移行细胞癌生物学行为的关系

目的　探讨细胞周期蛋白p2 7和cyclinE表达与膀胱移行细胞癌生物学行为的关系。 方法　对 12 1例膀胱移行细胞癌进行组织病理学分级及分期 ,另取 10例正常膀胱组织作对照 ,采用免疫组织化学SABC法检测各例组织中 p2 7和cyclinE蛋白表达水平 ,并分析其表达与临床病理特征的关系。结果　p2 7和cyclinE蛋白阳性表达率分别为 42 .1% ( 5 1/12 1)和 3 4.7% ( 4 2 /12 1)。p2 7和cyclinE蛋白表达均与肿瘤的组织学分级显著相关 ,但与病理分期无关。p2 7蛋白与cyclinE蛋白表达呈负相关 (P<0 .0 5 )。p2 7阴性组中 ,cyclinE阳性患者 5年生存率低于cyclinE阴性者 (P <0 .0 5 ) ;p2 7阳性组中 ,cyclinE表达状况与患者 5年生存率无显著相关。结论　p2 7和cyclinE是评估膀胱移行细胞癌预后的有价值的指标

Expression and Significance of p27 and cyclin E in Bladder Transitional Cell Carcinoma

Objective To investigate the significance of the protein expression of p27 and cyclin E in the progression and prognosis of bladder transitional cell carcinoma.Methods The pathological stage and histological grade were assessed in 121 patients with bladder transitional cell carcinoma.The expression of p27 and cyclin E was tested by immunohistochemical staining.Results The expression rate of p27 and cyclin E was 42.1% and 34.7%,respectively.Both p27 and cyclin E expression were related to histological grade of tumors but not to the pathological stage.A negative correlation was observed between p27 and cyclin E expression(P<0.05).In patients with negative expression of p27,the five-year survival rate was lower in patients with positive expression of cyclin E than in those with negative expression of cyclin E(P<0.05).Patients with positive expression of cyclin E and low expression of p27 had a poor prognosis.In patients with positive expression of p27,the expression of cyclin E had no relation with the 5-year survival rate.Conclusion p27 and cyclin E are important prognostic factors for patients with bladder transitional cell carcinoma.