Evidence against a physiological role of cAMP in choleresis in dogs and rats. |
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| Authors: | R E Poupon M L Dol M Dumont S Erlinger |
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| Affiliation: | Unité de Recherches de Physiopathologie Hépatique, INSERM U 24, Hôpital Beaujon, 92118 Clichy Cedex, France |
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| Abstract: | The relationship between liver cAMP concentration and bile flow was studied after administration of several compounds which increase the bile acid independent flow (BAIF). In the dog, the three drugs tested (glucagon, aminophylline and DB cAMP1) increased bile flow whereas only two of them (glucagon and DB cAMP) increased liver cAMP concentrations. In the rat, none of the drugs tested (glucagon, aminophylline and MIX2) modified bile flow whereas two of them (glucagon and MIX) increased liver cAMP concentrations. Therefore, there were no parallel variations between the increase in liver cAMP concentrations and the increase in choleresis. Furthermore, (1) no relationship was found between the time course of accumulation of cAMP and the increase in bile flow and (2) no relationship was found between the magnitude of the cAMP accumulation and the increase in bile flow. These data do not support the view that cAMP has a physiological role in bile formation. |
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| Keywords: | Requests for reprints and correspondence should be addressed to: Renée Poupon Unité de Recherches de Physiopathologie Hépatique (INSERM U 24) Hôpital Beaujon 92118 Clichy Cedex France. |
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