| INVESTIGATION OF RELATIONSHIPS BETWEEN KI－67SCORE，DNA INDEX，AND HISTOLOGIC GRADEIN SOFT TISSUE SARCOMAS |
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| 引用本文： | 王亚农,施达仁,沈镇宙,张仁元,刘守业.INVESTIGATION OF RELATIONSHIPS BETWEEN KI－67SCORE，DNA INDEX，AND HISTOLOGIC GRADEIN SOFT TISSUE SARCOMAS[J].中国癌症研究,1996,8(1):55-59. |
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| 作者姓名： | 王亚农 施达仁 沈镇宙 张仁元 刘守业 |
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| 作者单位： | Department of Surgery，Department of Pathology，Cancer Hospital Shanghai Medical University，Shanghai 200032 |
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| 摘 要： | ＩＮＶＥＳＴＩＧＡＴＩＯＮＯＦＲＥＬＡＴＩＯＮＳＨＩＰＳＢＥＴＷＥＥＮＫＩ－６７ＳＣＯＲＥ，ＤＮＡＩＮＤＥＸ，ＡＮＤＨＩＳＴＯＬＯＧＩＣＧＲＡＤＥＩＮＳＯＦＴＴＩＳＳＵＥ ＳＡＲＣＯＭＡＳＷａｎｇｙａｎｏｎｇ王亚农；ＳｈｉＤａｒｅｎ施达仁；ＳｈｅｎＺ...
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| 收稿时间： | 26 January 1996 |
Investigation of relationships between KI-67 score,DNA index,and histologic grade in soft tissue sarcomas |
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| Wang Yanong,Shi Daren,Shen Zhenzhou,Zhang Renyuan,Liu Shouye.Investigation of relationships between KI-67 score,DNA index,and histologic grade in soft tissue sarcomas[J].Chinese Journal of Cancer Research,1996,8(1):55-59. |
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| Authors: | Wang Yanong Shi Daren Shen Zhenzhou Zhang Renyuan Liu Shouye |
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| Institution: | (1) Department of Surgery, Cancer Hospital, Shanghai Medical University, 200032 Shanghai;(2) Department of Pathology, Cancer Hospital, Shanghai Medical University, 200032 Shanghai |
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| Abstract: | Proliferative activity of soft tissue sarcomas(STS)in 31 cases was estimated by histologic grading, mitotic count, DNA analysis by flow cytometry, and immunohistochemical procedures with monoclonal antibody Ki-67.Aneuploid was found in 12 of 16 cases(75.0%) with Grade 3, and in 4 of 15 cases(26.7%) with Grade 1, 2(P=0.0121).Tumors with more than 100 Ki-67 positive tumor cells per 10 high power fields(HPF) had a higher rate of aneuploid(81.3%) than those with less than 100 Ki-67 per 10 HPF (26.7%)(P=0.0038). There were significant correlations between Grade and DI (r=0.4901, P=0.0051), Grade and Ki-67(r=0.4636, P=0.0086), Ki-67 and DI(r=0-6368, P=0.0001). The results indicate that DI and reactivity of tumor cells to Ki-67 may reflect Proliferative activity and be helpful for clinicians to judge the biological behaviour of tumors more accurately and objectively. Supplementary to the grading of STS, DI and Ki-67 score could be useful as Prognostic parameters for clinical investigation of multimodality therapy for individual Patients. |
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| Keywords: | Soft tissue sarcomas Ki-67 antibody Flow cytometry Histologic grade |
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