Ang-(1-7)在急性呼吸窘迫综合征中的肺保护作用

肺组织局部的肾素-血管紧张素系统(RAS)与急性呼吸窘迫综合征(ARDS)关系密切,血管紧张素Ⅱ(AngⅡ)通过其1型受体激活肺部炎症反应,促进ARDS发生发展.血管紧张素-(1-7)Ang-(1-7)]也是RAS中得重要重要组分之一,能拮抗AngⅡ的生物学作用,被认为是AngⅡ的内源性拮抗剂.在ARDS中,Ang-(1-7)可能通过抑制炎症反应、减轻肺组织纤维化以及抗肺动脉高压等途径发挥肺保护作用,在ARDS中具有广阔的应用前景.

Recent advances of Angiotensin-(1-7) for the treatment of acute respiratory distress syndrome

It has been demonstrated that renin-angiotensin system (RAS)was involved in the pathogenesis of acute respiratory distress syndrome (ARDS). Angiotensin Ⅱ (Ang Ⅱ ), which is the main effector of RAS,could activate pulmonary inflammation through its receptor ATIR in ARDS. While recent findings has suggested that Angtensin-(1-7)Ang-(1-7)],the endougenous antagonist of Ang Ⅱ in RAS,could counter-regulate some pathological changes of Ang Ⅱ such as inflammation, fibrosis and pulmonary hypertension. These results indicate that Ang-(1-7) may protect from ARDS. In this review,we will focus on the recent findings related to the potential beneficial aspects of Ang-(1-7) in ARDS.