Increased feeding and hyperglycemia elicited by intracerebroventricular 5-thioglucose |
| |
| Authors: | Peter G. Slusser Robert C. Ritter |
| |
| Affiliation: | 1. Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Wash. 99164 USA;2. Department of Veterinary Science, University of Idaho, Mascow, Idaho 83843 U.S.A. |
| |
| Abstract: | 5-Thioglucose (5-TG) is a glucose analogue in which sulfur is substituted for the pyranose ring oxygen. Intracerebroventricular infusion of 5-TG caused prompt initiation of feeding and a marked rise in plasma glucose concentration at doses as low as 0.54 mumol (106 microgram). 5-TG is, therefore, more potent for eliciting feeding than any other previously tested glucose antimetabolite. The potency of 5-TG for eliciting feeding should make 5-TG a useful tool for localizing brain glucoreceptors which participate in the control of food intake. |
| |
| Keywords: | feeding behaviour 5-thioglucose 2-deoxyglucose glucoprivic control glucostasis |
| 本文献已被 ScienceDirect 等数据库收录！ |
