| 血清EPO及sTfR水平与恶性肿瘤性贫血的相关性研究 |
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| 引用本文： | 刘小芳,王凌云,杜涛,李俐佳,胡小彦,钟筑宁. 血清EPO及sTfR水平与恶性肿瘤性贫血的相关性研究[J]. 中国肿瘤临床与康复, 2010, 0(2): 107-110 |
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| 作者姓名： | 刘小芳 王凌云 杜涛 李俐佳 胡小彦 钟筑宁 |
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| 作者单位： | 贵阳市第一人民医院血液肿瘤科; |
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| 摘 要： | 目的探讨血清促红细胞生成素（erythropoietin,EPO）、可溶性转铁蛋白受体（soluble transferrin receptor,sTfR）水平和癌性贫血之间的关系,为临床合理使用重组人红细胞生成素（Recombinant Human Erythropietin,r-HuEPO）和铁剂治疗癌性贫血提供理论依据。方法采用酶联免疫分析方法（ELISA）测定60例癌性贫血患者血清EPO水平和sTfR水平,并将其与52例非癌性贫血患者的测定值及20例正常对照进行比较,以直线相关分析sTfR、EPO水平和Hb之间的关系。结果癌性贫血患者血清EPO、sTfR均较正常对照显著升高（P〈0.01）;癌性贫血患者血清EPO显著高于非癌性贫血患者（P〈0.05）;癌性贫血患者sTfR高于非癌性贫血患者,差异无显著性（P〉0.05）;癌性贫血患者血清EPO、sTfR升高的程度与贫血严重程度一致,与Hb值存在负相关,但与病期无明显相关性;EPO和sTfR之间无相关性。结论恶性肿瘤患者的血清EPO和sTfR水平能较好地反映其贫血病因,对贫血的治疗以及预后判断有一定的临床参考价值。
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| 关 键 词： | sTfR EPO 恶性肿瘤性贫血 |
Study on the relationship between the levels of EPO,sTfR in serum and cancer-related anemia |
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| Affiliation: | LIU Xiao-fang,WANG Ling-yun,DU Tao,et al(Department of Hematology and Oncology,The First People′s Hospital of Guiyang City,Guiyang,Guizhou 550002,China) |
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| Abstract: | Objective To explore the relationship between the levels of erythropoietin(EPO),soluble transferrin receptor(sTfR) in serum and cancer-related anemia,and provide the evidences for the treatment with rHuEPO and chalybeate in patients with cancer-related anemia.Methods The levels of EPO and sTfR in serum were detected by a sensitive enzyme-linked immunosorbent assay(ELISA) technique in 60 patients with cancer-related anemia,52 patients with non-cancer-related anemia and 20 normal controls.The relationship bet... |
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| Keywords: | sTfR EPO cancer-related anemia |
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