超敏C反应蛋白与急性冠脉综合征的相关性研究

目的探讨超敏C反应蛋白（hs-CRP）水平与急性冠脉综合征（ACS）的相关性。方法选取我院2009年2月至2011年2月的ACS患者80例作为ACS组，其中急性心肌梗死（AMI）患者38例、不稳定型心绞痛（uA）患者42例；另外选取同期健康体检者80名作为对照组。采用免疫透射比浊法检测两组急性期血清hs-CRP水平，并对检测结果进行分析比较。结果ACS组hs-CRP水平AMI组（25．45±7．56）mg／L，uA组（14．54±4．55）mg／L]与对照组（3．45±1．04）mg／L]比较，差异均有统计学意义（P〈O．01），AMI组hs-CRP水平高于uA组（P〈0．05）。血清hs—CRP水平是ACS的独立危险因素（AMI组：OR=1．54，P〈0．01；UA组：OR=1．46，P〈0．01）。结论血清hs-CRP水平可以反映心肌损害的程度，是ACS发病的独立危险因素，可作为判断ACS发生发展及预后评价的较好指标。

Study on the relationship of hypersensitive C-reactive protein and acute coronary syndrome

Objective To study the relationship of hypersensitive C-reactive protein（hs-CRP） and acute coronary syndrome （ACS）. Methods 80 cases of ACS patients from February 2009 and February 2011 in our hospital were collected as ACS group, included 38 eases of patients with acute myocardial infarction and 42 cases of patients with unstable type of angina （UA）. 80 eases of health people were selected as control group. The serum hs-CRP was detected by immunoturbidimetrie method in the two groups, and the results were analyzed. Results The level of hs-CRP in AMI group was（25.45±7.56）mg/L, in UA group was（14.54±5.55）mg/L, and in the con- trol group was （3.45±1.04）mg/L, compared with control group, there were significant differences （P〈0.01）. The level of hs-CRP in the AMI group was higher than that of the UA group （P〈0.05）. Logistic regression analysis showed that serum hs-CRP was a risk factor with ACS （AMI：OR=1.54, P〈0.01 ,UA：OR=1.46, P〈0.01）. Con- clusion The serum hs-CRP can reflect the degree of myocardial damage, is single risk factor of ACS, and could be as a good index to estimate the development and prognosis of ACS.