三种头孢菌素类抗生素治疗下呼吸道感染的成本-效果分析

目的评价3种头孢菌素类抗生素治疗下呼吸道感染的成本与效果。方法将126例下呼吸道感染患者随机分成A、B、C3组。A组给予头孢呋辛钠1．5g，iv gtt，tid；B组给予头孢曲松钠2．0g，iv gtt，qd；C组给予头孢哌酮钠2．0g，iv gtt，bid；疗程均为7d。观察3组的临床疗效，并进行成本-效果分析。结果A、B、C3组的有效率分别为83．33％、84．09％和82．50％，差异无统计学意义（P〉0．05）；3组的治疗成本分别为760．20圆、701．40圆和1128．40圆；成本-效果比分别为9．12、8．34和13．68。结论头孢曲松钠（2．0g，iv gtt，qd）是治疗下呼吸道感染的较佳方案。

Cost-effectiveness analysis of three therapeutic schemes for lower respiratory tract infection

AIM To compare the cost-effectiveness of three antibacterial drugs in the treatment of lower respiratory tract infection. METHODS A total of 126 patients with lower respiratory tract infection were divided into 3 groups （group A, group B and group C）. Group A was given 1.5 g cefuroxime sodium, iv gtt, tid, group B was given 2.0 g ceftriaxone sodium, iv gtt, qd and group C was given 2.0 g cefoperazone sodium, iv gtt, bid, for 7d. RESULTS The effective rate in 3 groups was not significantly different （P 〉 0.05）. The therapeutic costs were 760.20 CNY, 701.40 CNY and 1 128.40 CNY, respectively. The cost-effectiveness ratio were 9.12,8.34 and 13.68,respectively. CONCLUSION Ceftriaxone sodium is the best choice for the treatment of lower respiratory tract infecion.