瑞舒伐他汀对急性心肌梗死患者血清炎症因子和脂联素水平的影响

目的比较瑞舒伐他汀与阿托伐他汀对急性心肌梗死（AMI）患者的血清胆固醇（TC）、低密度脂蛋白（LDL-C）、高敏c反应蛋白（hs-CRP）、可溶性白细胞分化抗原40配体（sCD40L）和脂联素（APN）水平的影响。方法选择54例AMI患者，随机分为瑞舒伐他汀组（瑞舒伐他汀10～20mg，qd，28例）和阿托伐他汀组（阿托伐他汀20-40mg，qa，26例），分别检测治疗前及治疗4周后2组患者TC、LDL-C、hs—CRP、sCD40L和APN水平。结果瑞舒伐他汀组和阿托伐他汀组治疗后血清，TC、LDL-C、hs-CRP、sCD40L水平较治疗前明显降低，APN水平明显升高，差异有统计学意义（P〈0．05）。治疗4周后瑞舒伐他汀组血清hs-CRP、sCD40L水平与阿托伐他汀组相比明显降低，APN水平明显升高，差异有统计学意义（P〈0．05）。结论瑞舒伐他汀和阿托伐他汀都能降低TC、LDL-C、sCD40L、hs—CRP水平，升高APN水平，但瑞舒伐他汀治疗急性心肌梗死的效果明显优于阿托伐他汀。

Effects of rosuvastatin on inflammatory factors and adiponectin in patients with acute myocardial infarction

A/M To compare the effects of rosuvastatin and atorvastatin on serum total cholesteml（TC）, low-density lipoprotein （LDL-C）, high sensitivity C-reactive protein （hs-CRP）, soluble leukocyte differentiation antigen 40 ligand （sCD40L） and adiponectin（APN） in patients with acute myocardial infarction （AMI）. METHODS Fifty-four patients with acute myocardial infarction were randomly divided into rosuvastatin group （rosuvastatin 10 - 20 mg, qd, n = 28 ） and atorvastatin group （atorvastatin 20 - 40 rag, qd, n = 26）. The levels of TC, LDL-C, hs-CRP, sCD40L and APN were measured before and 4 weeks after treatment. RESULTS Sentm levels of TC, LDL-C, hs-CRP, sCD40L were significantly decreased and serum levels of APN were significantly increased after treatment with msuvastatin or atorvastatin （ P 〈 0.05）. Serum levels of hs-CRP, sCD40L were significantly lower and serum levels of APN was significantly higher 4 weeks after treatment with rosuvastatin compared with treatment with atorvastatin （ P 〈 0.05） . CONCLUSION Serum levels of LDL-C, hs-CRP and sCD40L could be reduced, and APN could be increased by treatment with either rosuvastatin or atorvastatin. Rosuvastatin has a stronger effect than atorvastatin.