Adult community-acquired pneumonia caused by macrolide resistant Mycoplasma pneumoniae |
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| Authors: | Rie ISOZUMI Hiroyuki YOSHIMINE Miyuki MOROZUMI Kimiko UBUKATA AND Koya ARIYOSHI |
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| Affiliation: | Inoue Hospital, and;Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, and;Laboratory of Molecular Epidemiology for Infectious Agents, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan |
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| Abstract: | A 28-year-old woman with community-acquired pneumonia was treated with sulbactam/ampicillin and clarithromycin, but failed to show any improvement after 4 days. The antibiotic regimen was changed to pazufloxacin and rapid clinical improvement was seen. Mycoplasma pneumoniae was identified as the causative agent, and adenine (A) to guanine (G) mutation at position 2063 in domain V of the 23S rRNA was noted in the isolate. The minimum inhibitory concentration of macrolide antibiotics, including clarithromycin, of this isolate was greatly elevated. |
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| Keywords: | macrolide resistance Mycoplasma pneumoniae pneumonia 23S rRNA mutation |
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