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| 胃癌及癌旁组织Fas蛋白和CD44V6蛋白的表达及其临床意义 | |
| 引用本文： | 张博芬,张玲,刘新,王文奎,王雅林,王宇.胃癌及癌旁组织Fas蛋白和CD44V6蛋白的表达及其临床意义[J].实用癌症杂志,2003,18(3):250-252. |
| 作者姓名： | 张博芬 张玲 刘新 王文奎 王雅林 王宇 |
| 作者单位： | 1. 110034,沈阳医学院免疫学教研室 2. 110034,沈阳医学院病理学教研室 3. 110015,辽宁省肿瘤医院 4. 100080,中国科学院微生物研究所 |
| 摘 要： | 目的 探讨Fas蛋白、CD44V 6蛋白在胃癌及癌旁组织的表达及其临床意义。方法 采用免疫组化SP法分别检测5 7例胃癌组织 ,5 7例癌旁组织和 2 0例正常胃黏膜组织中Fas蛋白、CD44V 6蛋白的表达。结果 5 7例胃癌组织中Fas蛋白表达的阳性率为 35 .0 9% ,5 7例癌旁组织为 70 .18% ,正常胃黏膜为 85 .0 0 % ,胃癌组织与癌旁组织 ,正常胃黏膜组织Fas蛋白的表达比较均有非常显著性差异 (P <0 .0 1)。CD44V 6蛋白的表达 ,胃癌组为 66.67% ,癌旁组为 2 2 .81% ,正常胃黏膜为 10 .0 0 % ,胃癌组织与癌旁组织 ,正常胃黏膜组织之间的CD44V 6蛋白的表达均有非常显著性差异 (P <0 .0 1)。结论 Fas蛋白、CD44V 6蛋白的表达对阐明胃癌的发生机制、预后和转移均有重要意义 |
| 关 键 词： | 胃癌 免疫组织化学 Fas蛋白 CD44V6蛋白 |
| 文章编号： | 1001-5930(2003)03-0250-03 |
| 修稿时间： | 2002年11月18 |
Expression and Clinical Significance of Fas and CD44V6 in Human Gastric Cancer and Cancer Surrounding Tissue |
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| ZHANG Bo-fen,ZHANG Ling,LIU Xin,et al..Expression and Clinical Significance of Fas and CD44V6 in Human Gastric Cancer and Cancer Surrounding Tissue[J].The Practical Journal of Cancer,2003,18(3):250-252. | |
| Authors: | ZHANG Bo-fen ZHANG Ling LIU Xin |
| Institution: | ZHANG Bo-fen,ZHANG Ling,LIU Xin,et al. Medical College of Shenyang,Shenyang,110034 |
| Abstract: | Objective To study the expression and clinical significance of Fas,CD44V6 in human gastric cancer and cancer surrounding tissue.Methods The expression of Fas,CD44v6 was analyzed by immunohistochemical staining S-P in 57 gastric cancer,57 cancer surrounding tissue and 20 normal gastric tissues.Results The positive expression rate of Fas was 35.09% in gastric cancer,70.18% in cancer surrounding tissue and 85.00% in normal gastric tissue.The positive expression rate of CD44V6 was 66.67% in gastric cancer,22.81% in paracancerous tissue and 10.00% in normal gastric tissue.The expression of Fas and CD44V6 was significantly different either between gastric cancer and paracancerous tissue or between gastric cancer and normal gastric tissue(P< 0.01).Conclusion The expression of Fas,CD44V6 has important significance for the study of developing mechnism,prognosis and metastasis of gastric cancer. |
| Keywords: | Castric cancer Immunohistochemistry Fas protein CD44V6 protein |
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