奇宁联合氟脲嘧啶、亚叶酸钙治疗晚期大肠癌的临床研究

目的比较奇宁注射液(斑蝥酸钠注射液)联合氟脲嘧啶、亚叶酸钙(治疗组)与传统大肠癌化疗方案(对照组)治疗大肠癌的疗效及毒性.方法治疗组38例,奇宁(Sodium Cantharidate)0.3mg,亚叶酸钙(CF)200mg/m2,5-氟尿嘧啶(5-Fu)375mg/m2静脉滴注第1～10d;对照组38例,CF 200mg/m2, 5-Fu375mg/m2静脉滴注第1～10d.结果治疗组有效率(39.5%),高于对照组(18.4%),统计学上有显著性差异(P＜0.05);血液学毒副作用治疗组明显低于对照组(P＜0.05).结论该研究表明,奇宁联合5-Fu和CF治疗大肠癌患者,缓解率较高,毒性相对较弱,值得进一步临床研究.

Clinical Study on Sodium Cantharidate Combined with 5-Fu and CF Treatment of Advanced Colorectal Cancer

Objective To compare the efficacy and toxicity of in patients with advanced colorectal cancer. Methods Seventy-six patients were enrolled in this study.38 patients(treatment group)received chemotherapy regimen of sodium cantharidate 0 3mg,CF 200mg/m 2, and 5-Fu 375mg/m 2 intravenous infusion from the first day to the tenth day. 38 patients(control group)received chemotherapy regimen of CF 200mg/m 2 and 5-Fu 375mg/m 2 intravenous infusion from the first day to the tenth day. ALL patients underwent two cycles of the therapy at least. Results The efficacy of the treatment group and control group was 39 5% and 18 4% respectively, which had a significant difference. The hematologic toxicities in the treatment group, especially leukopenia and anemia, were significantly than those in the control group less. Conlusion The results indicated that sodium cantharidate combined with 5-FU and CF treatment of colorectal cancer had moderate activity and less toxicity, further clinical investigation of which should be performed.