环氧化酶-2蛋白在复发性原发上皮性卵巢癌中的表达 |
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引用本文: | 冯继良,吴强,左连富,刘江惠,沈宗丽,张兰胜. 环氧化酶-2蛋白在复发性原发上皮性卵巢癌中的表达[J]. 中华肿瘤防治杂志, 2004, 11(6): 618-621 |
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作者姓名: | 冯继良 吴强 左连富 刘江惠 沈宗丽 张兰胜 |
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作者单位: | 1. 徐州市妇幼保健院妇科,江苏,徐州,221009 2. 江苏省肿瘤医院妇瘤科,江苏,南京,210009 3. 河北省肿瘤研究所流式细胞室,河北,石家庄,050011 4. 江苏省肿瘤研究所流式细胞室,江苏,南京,210009 5. 徐州医学院第二附属医院,江苏,徐州,221009 |
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摘 要: | 目的 :探讨环氧化酶 -2 (cyclooxygenase 2 ,COX 2 )与上皮性卵巢癌化疗疗效 (耐药或敏感 )及临床病理的关系。方法 :1999年 1月~ 2 0 0 3年 6月 ,从临床资料及随访资料完整的卵巢癌病例中筛选出 60例原发上皮性卵巢癌 (primaryepitheliaovariancarcino ma ,PEOC)作为研究对象。另选取 6例宫颈癌切除术后病理证实双卵巢为正常组织的病例作为对照。根据临床诊断、初治后复发时间等因素将 60例卵巢癌患者分为化疗耐药组 ( 3 0例 )和化疗敏感组 ( 3 0例 )。与 6例正常人作为对照组全部 66例均有随访结果。用流式细胞术定量分析 66例标本组织中COX 2蛋白的表达量。结果 :COX 2蛋白的表达量化疗耐药组 >化疗敏感组 >正常卵巢组织 ,单向方差分析两两比较差异均有统计学意义 ,P <0 0 0 5。随临床分期、病理分级、化疗疗程数的增加及有淋巴结转移 ,COX 2蛋白的表达量也随之增加 ,但是差异无统计学意义 ,P >0 0 5。结论 :COX 2蛋白的表达量与上皮性卵巢癌的复发、发展及疗程有关 ,与化疗耐药呈正相关。
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关 键 词: | 卵巢肿瘤/病理学 氧化还原酶类 药物耐受性 流式细胞术 |
文章编号: | 1009-4571(2004)06-0618-04 |
修稿时间: | 2003-11-11 |
Expression of COX-2 protein in primary epithelia ovarian cancer of chemotherapy resistance |
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Abstract: | OBJECTIVE:To explore the relation among the expression of COX-2 protein,and curative effect of chemotherapy and clinical pathology in primary epithelia ovarion cancer (PEOC).METHODS:The paraffin-embedded samples of 60 cases with PEOC and 6 cases with normal ovarian were selected from January,1999 to June,2003 were selected.All of them were divided into three groups:1)drug-resistance group (30 cases),2)drug-sensitive group (30 cases),3)normal ovarian group (6 cases,as controls).COX-2 protein were detected respectively in 66 samples by flow cytometry (FCM).RESULTS: The expression of COX-2 protein had significant difference among the three groups,1)>2)>3),P<0.005 .It had no differences among clinical stage,pathology grade,courses of chemotherapy and lymph node metastasis though it had increased with their increasing,P>0.05.CONCLUSION: The expression of COX-2 has positive relation to chemotherapy resistance to PEOC,also has correlation to its recurrence, development and courses of chemotherapy. |
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Keywords: | ovarian neoplasms/pathology oxidoreductase drug resistance flow cytometry |
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